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World Congress on Biosensors 2014

World Congress on Biosensors 2014
Biosensors 2014

Wednesday, 31 August 2011

News from the Colloquium Spectroscopicum Internationale XXXVII

I am currently attending the Colloquium Spectroscopicum Internationale XXXVII in Buzios near Rio de Janeiro and thought readers would like to get a flavour for the conference.

The following video shows some post-session entertainment spoiled when an irrate author confronted and editor over a rejected paper ...
video

Just Published: Biosensors & Bioelectronics

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

A one-step electrochemical method for DNA detection that utilizes a peroxidase-mimicking DNAzyme amplified through PCR of target DNA

30 August 2011, 20:43:27Go to full article
Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 30 August 2011
Byoung Yeon, Won , Sujeong, Shin , Rongzhan, Fu , Sung Chul, Shin , Dae-Yeon, Cho , ...
A novel one-step electrochemical method for DNA detection is described. The procedure utilizes a reaction catalyzed by a peroxidase-mimicking DNAzyme to produce a product, which forms an insoluble precipitation layer on the surface of an electrode. A rationally designed forward primer, conjugated with a peroxidase DNAzyme complementary sequence at its 5′-end, is used for PCR amplification of target DNA. As a result, the DNAzyme sequence is produced by amplification only when the target DNA is present in the sample. The PCR product is then subjected to the precipitation reaction on the electrode surface using an electrolyte assay buffer containing 4-chloronaphthol,...

Effects of sulfide on microbial fuel cells with platinum and nitrogen-doped carbon powder cathodes

30 August 2011, 20:43:27Go to full article
Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 30 August 2011
Yujie, Feng , Xinxin, Shi , Xin, Wang , He, Lee , Jia, Liu , ...
Because of the advantages of low cost, good electrical conductivity and high oxidation resistance, nitrogen-doped carbon (NDC) materials have a potential to replace noble metals in microbial fuel cells (MFCs) for wastewater treatment. In spite of a large volume of studies on NDC materials as catalysts for oxygen reduction reaction, the influence of sulfide on NDC materials has not yet been explicitly reported so far. In this communication, nitrogen-doped carbon powders (NDCP) were prepared by treating carbon powders in nitric acid under reflux condition. Sodium sulfide (Na2S) was added to the cathodic electrolyte to compare its effects on platinum (Pt)...

A multi-amplification aptasensor for highly sensitive detection of thrombin based on high-quality hollow CoPt nanoparticles decorated graphene

28 August 2011, 20:42:38Go to full article
Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 27 August 2011
Yan, Wang , Ruo, Yuan , Yaqin, Chai , Yali, Yuan , Lijuan, Bai , ...
In this work, we have successfully demonstrated a facile strategy to incorporate high-quality hollow CoPt bimetal alloy nanoparticles (HCoPt) onto reduced graphene oxide sheet (HCoPt-RGs). An advanced sandwich-type electrochemical aptasensor for thrombin was proposed by using the HCoPt-RGs conjugates as secondary label. The formed conjugates provided large surface area for loading plentiful redox probe thionine (Thi), horseradish peroxidase (HRP) and secondary aptamer (Apt II) with good stability and friendly biocompatibility, indicating its superior properties in electroactive mediater enrichment and biomolecule immobilization. Furthermore, activated by glutaraldehyde (GA), the chitosan-hollow CoPt alloy nanoparticles (CS-HCoPt) film can greatly facilitate the capture of primary...

Development of a prototype wound dressing technology which can detect and report colonization by pathogenic bacteria

28 August 2011, 20:42:38Go to full article
Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 27 August 2011
Jin, Zhou , ThetNaing, Tun , Sung-ha, Hong , June D., Mercer-Chalmers , Maisem, Laabei , ...
A new methodology for detecting the microbiological state of a wound dressing in terms of its colonization with pathogenic bacteria such as Staphylococcus aureus or Pseudomonas aeruginosa has been developed. Here we report how stabilized lipid vesicles containing self-quenched carboxy-fluorescein dye are sensitive to lysis only by toxins/virulence factors from P. aeruginosa and S. aureus but not by a non-toxic E. coli species. The development of the stabilized vesicles is discussed and their response to detergent (triton), bacterial toxin (α-hemolysin)and lipases(phospholipase A2). Finally, fabrics with stabilized vesicles attached via plasma deposited maleic anhydride coupling are shown visibly responding to S....

Just Published: Sensors & Actuators A: Physical

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
http://rss.sciencedirect.com/publication/science/5282
Selected papers from the latest issue:

Sorption characterization and actuation of a gas-gap heat switch

28 August 2011, 23:22:21Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 27 August 2011
D., Martins , L., Ribeiro , D., Lopes , I., Catarino , I.A.A.C., Esteves , ...
Cryogenic gas-gap heat switches are rendered compact by using a sorption pump as actuating device. The sorption pump adsorbs gas when it is cooled and releases gas when it is heated. Upon desorption, the released gas lies in the gap between two blocks and increases the conduction heat transfer between them; in the reverse case - when the gas is adsorbed - the gap space between the two blocks behaves as an insulator. The temperatures at which there is sufficient desorption and adsorption of gas for actuating the ON an OFF states depend on several parameters of the gas-adsorbent system....

Study of magnetic ranging technology in horizontal directional drilling

26 August 2011, 20:52:14Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 26 August 2011
Tao, Liu , Boxiong, Wang
Intersection technology plays a key role in long-distance horizontal directional drilling (HDD). Magnetic ranging technology is an effective way to realize the intersection. A three-dimensional magnetic field model suitable for the cylindrical magnet connected with drilling bit was established. New formulae of magnetic induction intensity were deduced from the fundamental formulae to suit to the new magnetic ranging method. Based on the new formulae, a curve fitting model was established to complete the ranging. The whole process is simple and effective. The result of the experiment proved the feasibility of the new method and the accuracy is high enough for...

Acoustically Generated Flows in Microchannel Flexural Plate Wave Sensors: Effects of Compressibility

26 August 2011, 20:52:14Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 26 August 2011
Ersin, Sayar , Bakhtier, Farouk
Acoustically generated flowfields in flexural plate wave sensors filled with a Newtonian liquid (water) are considered. A computational model based on compressible flow is developed for the sensor with a moving wall for pumping and mixing applications in microchannels. For the compressible flow formulation, an isothermal equation of state for water is employed. The velocity and pressure profiles for different parameters including flexural wall frequency, channel height, amplitude of the wave and wave length are investigated for four microchannel height/length geometries. It is found that the flowfield becomes pseudo-steady after sufficient number of flexural cycles. Both instantaneous and time averaged...

Measuring High Viscosity is a Breeze with µVISC™

RheoSense, Inc. has released a new viscometer, µVISC™ (micro VISC), the newest product from core VROC® technology.
HC, the newest chip, supports testing of higher viscosity ranges up to 20,000 mPas or higher.
With the NEW HC chip, this cost-effective instrument provides for easy and rapid viscosity measurements and now supports a wider range of applications. This technical combination supports industry demands for tighter quality control and fast and timely decision making.
With a simple 1-2-3 step operation, tests are completed within a minute. With the easy to use menu-driven application program, the user can view graphs of the results and generate a report with the touch of a finger.
µVISC™ is an essential portable instrument for testing and evaluating materials such as inks, biologics, chemicals, oils, and other liquids.
VROC® is the registered trade mark of RheoSense, Inc, an acronym of Viscometer-Rheometer-on-a-chip. It is the only chip based viscometer. The applied measurement principle is well known for simplicity and accuracy in the rheology field and described in most rheology textbooks. Some ISO methods also adopt the core principle.
For additional information about the new µVISC®, contact RheoSense, Inc., 2678 Bishop Drive, Suite 270, San Ramon, CA 94583 USA.
Phone: 925-866-3802
Fax: 925-866-3804
E-mail: info@rheosense.com
or visit our Web site: http://www.rheosense.com/

Tuesday, 30 August 2011

Just Published: Talanta

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

Use of carbon nanotubes and electrothermal atomic absorption spectrometry for the speciation of very low amounts of arsenic and antimony in waters

28 August 2011, 20:07:53Go to full article
Publication year: 2011
Source: Talanta, In Press, Accepted Manuscript, Available online 27 August 2011
Ignacio, López-García , Ricardo E., Rivas , Manuel, Hernández-Córdoba
A procedure for the determination of inorganic arsenic (III,V) and antimony (III,V) in water samples by using a miniaturized solid-phase extraction with carbon nanotubes followed by electrothermal atomic absorption measurement is proposed. The trivalent species are first complexed with ammonium pyrrolidinedithiocarbamate, next retained in a mini-column containing nanotubes and then eluted by means of a plug of an ammonia solution. The atomizer is impregnated with a tungsten salt which acts as an effective chemical modifier during the heating cycle. Total inorganic arsenic and antimony are determined after the reduction of the pentavalent forms with an ammonium iodide solution. Pentavalent arsenic...

Synthesis of molecularly-imprinted monolithic fibers for solid-phase microextraction of acetaldehyde from head-space of beverages stored in PET bottles

28 August 2011, 20:07:53Go to full article
Publication year: 2011
Source: Talanta, In Press, Accepted Manuscript, Available online 27 August 2011
A. Rajabi, Khorrami , E., Narouenezhad
Molecularly-imprinted monolithic fibers were synthesized and evaluated for solid-phase microextraction (SPME) of acetaldehyde from head-space of beverages stored in poly(ethylene terephthalate) (PET) bottles. The fibers were prepared by co-polymerization of methacrylic acid and ethylene glycole diethacrylate as functional monomer and cross-linker, respectively. Acetaldehyde was used as template molecule during polymerization process, in order to leave specific cavities after leaching off from the co-polymer. Narrow bore (i.d. 100μm) glass capillaries as molds were filled with polymerization mixture containing cross linker, functional monomer, template molecule, initiator and porogen solvent. This mixture is then polymerized to form a continuous porous monolith that conforms...
 Highlights: ► We synthesize an acetaldehyde-imprinted monolithic fiber. ► It selectively extracts acetaldehyde from head-space of beverages stored in PET bottles. ► The fiber shows promising mechanical and thermal stability. ► The derivatization step is not necessary. Good linear range and long durability are the other advantages.

Detecting Sub-Nanometre Molecules at Low Concentrations

Avid Nano have issued a new technical note demonstrating the excellent performance of its W130i Dynamic Light Scattering System for detecting and precisely measuring sub-nanometre particles and molecules.

The new technical note describes the ease with which a very small molecule with a low molecular weight (caffeine, MW 194.2 g/mol) was accurately measured at only 1.4% concentration in aqueous solution.

The results using the W130i DLS demonstrate that the light scattering signal from the dissolved caffeine is sufficient to produce a good quality correlogram with an intercept >0.2 and highly reproducible data with low polydispersity. The mean radius was consistently reported at about 0.48nm and molecular weight estimate around 400Da indicating concentration dependent self association into dimers, a known characteristic of caffeine in aqueous solutions.

Engineered to meet the demands of today's research laboratories, the W130i dynamic light scattering system delivers outstanding performance from only microlitres of sample in seconds. The W130i combines ultimate measurement performance with an economical benchtop footprint, rugged durability and supreme user convenience.
 
For a copy of Technical Note 1107-T4 please visit www.avidnano.com/downloads/downloads.htm or contact Avid Nano on +44-1494-614659 or email info@avidnano.com.  

Monday, 29 August 2011

Just Published: Journal of Pharmaceutical and Biomedical Analysis

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry

29 August 2011, 00:22:24Go to full article
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 27 August 2011
Xue, Qiao , Guan, Ye , Chun-fang, Liu , Zhi-xiang, Zhang , Qiang, Tu , ...
Eriocaulon buergerianum Koern. is the botanical source for the Chinese herbal medicine Gu-Jing-Cao. Other Eriocaulon species are also used as the same herb in local areas and are difficult to be differentiated. In order to improve the quality control of Gu-Jing-Cao, chemical constituents of E. buergerianum and adulterating species were analyzed by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MSn). The 70% methanol extracts were separated on a Zorbax SB-C18 column and eluted with acetonitrile-water (each containing 0.1% formic acid). The compounds were identified by ion-trap mass spectrometry in both positive and negative ion...

UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices

26 August 2011, 21:34:23Go to full article
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 26 August 2011
Antoine, Lévèques , Lucas, Actis-Goretta , Maarit J., Rein , Gary, Williamson , Fabiola, Dionisi , ...
Hesperidin (hesperetin-7-O-rutinoside), a flavonoid affecting vascular function, is abundant in citrus fruits and derived products such as juices. After oral administration, hesperidin is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside, the glucoside group is further cleaved and the resulting hesperetin is absorbed and metabolized. Flavanones have a chiral carbon generating (R)- and (S)-enantiomers, with potentially different biological activities. A rapid UPLC-MS/MS method for the analysis of (R)- and (S)-hesperetin enantiomers in human plasma and urine was developed and validated. Biological matrices were incubated with β-glucuronidase/sulfatase, and hesperetin was isolated by solid-phase extraction using 96-well plate mixed-mode cartridges having reversed-phase and...
 Highlights: ► Hesperidin (hesperetin-7-O-rutinoside) is a flavonoid abundant in citrus fruits and derived products such as juices. ► When hesperidin is consumed by humans, the rhamnose part of the rutinoside group is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside and hesperetin. ► Hesperidin exhibits potential health benefits. ► We developed and validated a rapid analytical method for accurate quantification of hesperetin and hesperetin enantiomers in human urine and plasma samples within a clinical trial.

Chemically Defined Stem Cell Cryopreservation Solution

STEM-CELLBANKER® from AMSBIO is a chemically defined freezing medium with optimized formulation for stem cells and iPS cells storage as well as other valuable cells. Supplied ready-to-use with a simple usage protocol, STEM-CELLBANKER® is completely free of serum and animal derived components, and contains only European or US Pharmacopoeia graded ingredients.

Part of the CELLBANKER® series of cell freezing media, STEM-CELLBANKER® significantly increases cell viability while maintaining cell pluripotency, normal karyotype and proliferation ability following resuscitation from cryopreservation, even after extended long-term storage. Independent research has demonstrated that hESC, MSCs and iPS cells cryopreserved with STEM-CELLBANKER® produce significantly higher cell viability (> 90%) over conventional freezing medium, while retaining cell pluripotency, normal karyotype and proliferation ability (1).

Every batch of STEM-CELLBANKER® cryopreservation medium is performance tested on Jurkat and SK-007 cells. Additional standard evaluations for endotoxins, pH, osmolarity and Mycoplasma contaminants are undertaken to ensure GMP equivalent quality.

For further information please visit www.amsbio.com/STEM-CELLBANKER-Stem-Cell-Cryopreservation-Solution.aspx or contact AMSBIO on +44-1235-828200 / +1-949-768-8365 or email info@amsbio.com.

Friday, 26 August 2011

Just Published: Journal of Chromatography A

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

Comparison of monolithic and microparticulate columns for reversed-phase liquid chromatography of tryptic digests of industrial enzymes in cleaning products

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
M., Beneito-Cambra , J.M., Herrero-Martínez , G., Ramis-Ramos , W., Lindner , M., Lämmerhofer
Enzymes of several classes used in the formulations of cleaning products were characterized by trypsin digestion followed by HPLC with UV detection. A polymeric monolithic column (ProSwift) was used to optimize the separation of both the intact enzymes and their tryptic digests. This column was adequate for the quality control of raw industrial enzyme concentrates. Then, monolithic and microparticulate columns were compared for peptide analysis. Under optimized conditions, the analysis of tryptic digests of enzymes of different classes commonly used in the formulation of cleaning products was carried out. Number of peaks, peak capacity and global resolution were obtained in...

Structural identification of mouse fecal metabolites of theaflavin 3, 3′-digallate using liquid chromatography tandem mass spectrometry

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
Huadong, Chen , Tiffany A., Parks , Xiaoxin, Chen , Nicholas D., Gillitt , Christian, Jobin , ...
Black tea consumption has been associated with many health benefits including the prevention of cancer and heart disease. Theaflavins are the major bioactive polyphenols present in black tea. Unfortunately, limited information is available on their biotransformation. In the present study, we investigated the metabolic fate of theaflavin 3, 3′-digallate (TFDG), one of the most abundant and bioactive theaflavins, in mouse fecal samples using liquid chromatography/electrospray ionization tandem mass spectrometry by analyzing the MSn (n=1–3) spectra. Four metabolites theaflavin, theaflavin 3-gallate, theaflavin 3′-gallate, and gallic acid were identified as the major mouse fecal metabolites of TFDG. Glucuronidated and sulfated, instead of...

Preparation and evaluation of a porous monolithic capillary column for microextraction of estrogens from urine and milk samples online coupled to high-performance liquid chromatography

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
Yuling, Hu , Yifeng, Fan , Gongke, Li
A porous monolithic capillary column based on poly (methacrylic acid-co-ethylene glycol dimethacrylate) (poly (MAA-co-EGDMA)) was prepared using methanol and polyethylene glycol 6000 as mixed porogens. The monolith has the characteristics of good permeability, high extraction efficiency and long lifetime. Improved permeability of the monolith could realize sample loading with high flow rate. A simple and convenient construction that employed valve-switch technique was designed for online coupling of the monolithic capillary column to high performance liquid chromatography. In order to obtain optimum extraction efficiency, the extraction conditions including sample pH, sample volume, extraction and desorption flow rate were investigated. Under the...

Electromembrane Extraction of Stimulating Drugs from Undiluted Whole Blood

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
RagnhildElénGjulem, Jamt , Astrid, Gjelstad , Lars Erik Eng, Eibak , Elisabeth Leere, Øiestad , AsbjørgSolberg, Christophersen , ...
For the first time, electromembrane extraction (EME) of six basic drugs of abuse from undiluted whole blood and post mortem blood in a totally stagnant system is reported. Cathinone, methamphetamine, 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-methamphet-amine (MDMA), ketamine and 2,5-dimethoxy-4-iodoamphetamine (DOI) were extracted from the whole blood sample, through a supported liquid membrane (SLM) consisting of 1-ethyl-2-nitrobenzene (ENB) immobilized in the pores of a hollow fiber, and into an aqueous acceptor solution inside the lumen of the hollow fiber. The SLM acts as a barrier with efficient exclusion of all macromolecules and acidic substances in the sample. Due to the application of the...

Ultra high performance liquid chromatography-time of flight mass spectrometry for analysis of avocado fruit metabolites: method evaluation and applicability to the analysis of ripening degrees

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
Elena, Hurtado-Fernández , Tiziana, Pacchiarotta , María, Gómez-Romero , Bart, Schoenmaker , Rico, Derks , ...
We have developed an analytical method using UHPLC-UV/ESI-TOF MS for the comprehensive profiling of the metabolites found in the methanolic extracts of 13 different varieties of avocado at two different ripening degrees. Both chromatographic and detection parameters were optimized in order to maximize the number of compounds detected and the sensitivity. After achieving the optimum conditions, we performed a complete analytical validation of the method with respect to its linearity, sensitivity, precision, accuracy and possible matrix effects. The LODs ranged from 1.64 to 730.54 ppb (in negative polarity) for benzoic acid and chrysin, respectively, whilst they were found within the...

Characteristic fragmentation patterns of trimethylsilyl and trimethylsilyl-oxime derivatives of plant disaccharides as obtained by gas chromatography coupled to ion-trap mass spectrometry

25 August 2011, 20:49:03Go to full article
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 25 August 2011
I., Boldizsár , Zs., Füzfai , I., Molnár-Perl
The characteristic fragmentation pattern of six reducing and two non reducing type disaccharides - (neohesperidose, acuminose, sambubiose, rutinose, vicianose, primverose, and two arabinosyl-inositols) has been described. These saccharides have not been previously identified by on-line chromatographic techniques. Unambiguous specific characteristics of the TMS (oxime)’s such as mass distribution, syn/anti oximes ratios and elution order proved to be associated with their reducing or non reducing character, with their aldosyl property and with the position of their O-glycosidic linkages.The practical utility of the mass fragmentation study of these rare disaccharides was demonstrated, at the first time, by the simultaneous, on-line identification and...

Storage Tube Refill Packs

Tube refill packs from Micronic Europe provide you with a fast, easy-to-use and economic solution to refill your storage racks with 2D coded, alphanumeric or plain storage tubes. Micronic tube refills are also environmentally friendly - customers can simply refill their current storage rack thereby reducing their non-renewable plastic waste. To use simply place the refill pack containing 96 new tubes in one of your storage racks and push the refill carrier down. The tubes can then be retrieved as normal.

Available in a range of tube volumes (0.75ml and 1.40ml) - tube refills are available for the complete range of Micronic storage racks: Loborack-96, Comorack-96 and Roborack-96. Micronic tube refill packs are also available for use with other brands of storage racks.

Manufactured from highest medical grade polypropylene in a fully automated class 7 cleanroom environment ensures Micronic tube refill packs exhibit absolute product consistency, near zero contaminants and compliance with US and European Pharmacopoeia tests. Micronic refill tubes resist many organic solvents (DMSO, methanol, dichloromethane), may be autoclaved clean and can be repeatedly freeze-thawed without loss of product performance.

Dedicated to the design and production of innovative sample storage tubes, accessories and instruments over the last 25 years, Micronic is uniquely able to offer laboratories the expert advice to help them safeguard one of its most valuable assets - its samples.

For further detailed information please visit http://www.micronic.com/products/38/tube-refill-system or contact Micronic Europe BV now on +31-320-277070 / sales@micronic.com.

Advanced Performance from a Benchtop Freeze Dryer

SP Scientific has announced a new upgraded version of its market-leading Virtis AdVantage Plus laboratory benchtop freeze dryer.

The Advantage Plus now comes with an elegantly restyled exterior, easier shelving adjustment, and is equipped with the powerful Wizard 2.0 controller, the same process control software used on larger VirTis freeze dryers. The controller provides scientists with the ability to develop a complete freeze drying recipe, together with the flexibility to program and control individual pressure and temperature settings at each step of the process.

Incorporating silicone flooded shelves, the AdVantage Plus maintains a precise level of temperature control previously available only in pilot/production scale freeze dryers. Added operational convenience is provided by the newly designed condenser coil which can hold a total of six liters before defrosting. At only 26in (66cm) wide, the Advantage Plus requires a minimal amount of your valuable bench space yet enables product to be safely processed on over 3 ft2 (2,766 cm2) of usable shelf area.

The AdVantage Plus is a versatile system that can freeze dry bulk product or be configured for applications in stoppered vials. Side-mounted manifold valves provide the additional flexibility to freeze dry product in flasks. Three refrigeration choices (-53°C, -70°C, or -85°C) are available for the large 6-litre capacity condenser, depending on the type of product and solvents being lyophilized. Featuring the latest advances in benchtop freeze drying, the AdVantage Plus can be configured with up to three fluid-cooled shelves which maintain precise temperature control. The AdVantage Plus
comes with a two year refrigeration warranty and includes CE marking.

SP Scientific is a leading manufacturer of laboratory to production scale freeze dryers / lyophilizers, centrifugal evaporators and concentrators, thermal control system and glassware washers. The company sells its products under well-known brands including Hotpack®, VirTis®, FTS™ and Genevac®. SP Scientific has ISO 9001:2000 registered production facilities in the USA and Europe.

To learn about the new features on the AdVantage Plus please visit SP Scientific.com or contact the company on email FreezeDryers@SPScientific.com or telephone +1.845.255.5000 (+44-1473-240000 in Europe).

Thursday, 25 August 2011

Just Published: Journal of Chromatography B

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

Simultaneous UFLC–ESI–MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: Application to pharmacokinetic studies in rats

24 August 2011, 21:50:57Go to full article
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Junhui, Liu , Ying, Bi , Rong, Luo , Xia, Wu
The alkaloids from P. longum L showed protective effects on Parkinson's disease models in our previous study and piperine and piperlonguminine were the two main constituents in the alkaloids. The present study aimed at developing a rapid, sensitive, and accurate UFLC–ESI–MS/MS method and validating it for the simultaneous determination of piperine and piperlonguminine in rat plasma using terfenadine as the internal standard. The analytes and internal standard (IS) were extracted from rat plasma using a simple protein precipitation by adding methanol/acetonitrile (1: 1, v/v). A Phenomenex Gemini 3 u C18 column (20mm×2.00mm, 3 micrometer) was used to separate the analytes...

Online extraction toxicological MS(n) screening system for serum and heparinized plasma and comparison of screening results between plasma and urine in the context of clinical data

24 August 2011, 21:50:57Go to full article
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Daniel M., Mueller , Katharina M., Rentsch
 Background: The two main matrices for screening are urine or serum and heparinized plasma. Whereas urine has the advantage of usually higher concentrations and longer detection windows, serum or heparinized plasma represent the current systemic drug exposure of a patient. Materials and Methods: An online extraction LC-MSn method using a MS2 and MS3 spectral library for the identification of substances has been developed and validated to screen serum and heparinized plasma. Extraction was performed by online turbulent flow chromatography under alkaline conditions. Chromatographic separation was achieved using a phenyl/hexyl column with acidic eluents. For detection, a linear ion trap, equipped with an APCI...

Gas-chromatography-tandem mass spectrometry assay for the quantification of four benzodiazepines and citalopram in eleven postmortem rabbit fluids and tissues, with application to animal and human samples

24 August 2011, 21:50:57Go to full article
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
N., Cartiser , F., Bévalot , C., Le Meur , Y., Gaillard , D., Malicier , ...
Pharmacokinetic studies and postmortem toxicological investigations require a validated analytical technique to quantify drugs on a large number of matrices. Three-step liquid/liquid extraction with online derivatization (silylation) ahead of analysis by gas chromatography-tandem mass spectrometry was developed and validated on rabbit specimens in order to quantify citalopram and 4 benzodiazepines (diazepam, nordazepam, oxazepam and temazepam) in 11 biological matrices (blood, urine, bile, vitreous humor, liver, kidney, skeletal muscle, brain, adipose tissue, bone marrow (BM) and lung). Since the 11 biological matrices came from the same animal species, full validation was performed on 1 matrix, bone marrow (considered the most complex),...

STRONG ORGANIC GROWTH FUELS ACQUISITION FOR CHESHIRE B2B BUSINESS MARKETING AGENCY THE SCOTT PARTNERSHIP

Cheshire based B2B business marketing agency The Scott Partnership Ltd announces its acquisition of life science PR agency Kapler Communications Ltd.  The acquisition sees Kapler move into the holding company of The Scott Partnership Ltd to operate as a wholly owned stand-alone business.  

The Scott Partnership confirms that its consistent organic sales growth and expanding global footprint have together fuelled the acquisition, giving a three continent footprint with offices in the USA, China and now 2 in the UK.

This acquisition marks a significant step forward for The Scott Partnership in building international centres of excellence for B2B communications, delivered globally to life sciences and healthcare, chemicals and environmental clients.

CEO Kath Darlington explains “Kapler is a strong established business with a solid record of customer delivery in the life sciences and analytical field.  The two founders, Trish Appleton and Richard Kent, will remain in the business and bring the significant skills of their science-led team into The Scott Partnership.  Our strong growth record internationally can be exploited further by this acquisition, and sees The Scott Partnership growing its team both in terms of leadership and in terms of skills and resources.”

“The acquisition fits with our strategy for controlled growth, giving our clients access to exceptional skills and service in a global market”, she concludes.

For more information on The Scott Partnership, please call +44 (0)1477 539 539. Alternatively e-mail mailto:pr@scottpr.com or visit http://www.scottpr.com/.

Wednesday, 24 August 2011

The Ultimate Antibiotic Milk Testing Platform

Randox Food Diagnostics has developed and manufactured a unique multi-analyte milk testing platform.  Unlike many other commercially available milk testing products, the Randox multiplex platform offers limits of detection that are sub maximum residue/tolerance levels globally.  Up to 675 test results can be achieved in less than 2 hours using the Antimicrobial I Plus Array that can detect up to 14 sulphonamide compounds and Trimethoprim from a single milk sample.

The Antimicrobial II Array allows detection of multiple classes of antimicrobials including 17 quinolone compounds and 10 tetracycline compounds (including the epimers of oxytetracycline, tetracycline and chlortetracycline).  This array also includes tylosin, ceftiofur, streptomycin and florfenicol. 

The Beta Lactam Array, soon to be released, will allow detection of all penicillins and cephalosporins including Amoxicillin, Oxacillin, Penicillin G, Cefacetril and Ceftiofur.

Using the Evidence Investigator bench top analyser this testing platform can identify and provide a corresponding concentration for the antimicrobial class present in a sample, considerably reducing the number of confirmatory analyses required. 

Randox Food Diagnostics offer a cost effective milk testing platform which can considerably increase sample throughput while reducing labour.

For further information please refer to the Randox Food Diagnostics website http://www.randoxfooddiagnostics.com/ or email enquiries@randoxfooddiagnostics.com.

In Utero Electroporation Enables Ventricular Zone Studies in Mice

BTX ECM 830 square wave pulse technology was used to target and study the development of neural stem cells and progenitors in the developing mouse brain in utero. In a recent publication by Stancik, E. et al., researchers targeted the mouse ventricular zone (VZ) through electroporation using the 3 mm platinum Tweezertrodes to transfect cells in order to distinguish the cell cycle kinetics of the short neural and radial glial cells during the development of the cerebral cortex.
The wide range of square wave voltages, pulse lengths and multiple pulsing capability of the ECM 830 Square Wave generator make it ideal for this application. The ECM 830 coupled with the BTX specialty electrodes are widely used for a full range of in vivo, in utero and in ovo applications. In addition to the unique versatility of the ECM 830 for in vivo applications, the system is capable of efficiently transfecting in standard cuvettes or in a 96-well format.
Visit the BTX website at http://www.btxonline.com/ for more information on products, protocols or to view video tutorials for a variety of applications.
To learn more about this exciting technology or other BTX electroporation or electrofusion products, contact:
BTX84 October Hill Road
Holliston, Massachusetts 01746 USA
Toll Free: 800-272-2775
Phone: 508-893-8999 ext 167
Fax: 508-429-5732
E-mail: techsupport@btxonline.comWeb: http://www.btxonline.com/

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Tuesday, 23 August 2011

Just Published: Sensors & Actuators A: Physical

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

A Wireless And Passive Wafer Cleanliness Monitoring Unit Via Electromagnetic Coupling For Semicondutcor/Mems Manufacturing Facilities

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Xu, Zhang , Junseok, Chae
This paper presents a wireless and passive chemical sensing system, in-situ real time, via electromagnetic (EM) coupling, capable of monitoring wafer cleanliness during rinsing process at semiconductor/MEMS manufacturing facilities. A MEMS chemical sensor is embedded in a wafer-form transponder to evaluate the rinsing process in-situ by measuring the conductivity of rinsing water inside micro-features formed by two interdigitated electrodes. All necessary power for the transponder is supplied from an external interrogator via the on-wafer transponder antenna. The modulated conductivity data is then emitted back from the transponder to the external interrogator in wireless and battery-free manner. The wireless system has...

A novel humid electronic nose combined with an electronic tongue for assessing deterioration of wine

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Luis, Gil-Sánchez , Juan, Soto , Ramón, Martínez-Máñez , Eduardo, Garcia-Breijo , Javier, Ibáñez , ...
We report herein the use of a combined system for the analysis of the spoilage of wine when in contact with air. The system consists of a potentiometric electronic tongue and a humid electronic nose. The potentiometric electronic tongue was built with thick-film serigraphic techniques using commercially available resistances and conductors for hybrid electronic circuits; i.e. Ag, Au, Cu, Ru, AgCl, and C. The humid electronic nose was designed in order to detect vapours that emanate from the wine and are apprehended by a moist environment. The humid nose was constructed using a piece of thin cloth sewn, damped with...

Development of an AC Electrokinetics-Based Immunoassay System for On-site Serodiagnosis of Infectious Diseases

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Xiaozhu, Liu , Kai, Yang , Ashutosh, Wadhwa , Shigetoshi, Eda , Shanshan, Li , ...
This paper presents a lab-chip immunoassay system that is based on AC electrothermal effect. It uses a poly (dimethylsiloxane) based microfluidic cartridge as the disposable immunoreactor, on which key processes such as reagent delivery, incubation and washing are performed using low voltage AC signals. A low cost, reconfigurable detection module is constructed based on light emitting diode induced fluorescence. Along with the employed AC electrothermal effect, the developed diagnostic system has demonstrated a much shorter incubation time than conventional pressure driven flow system. A tenfold acceleration in detection is achieved while safely differentiating between the positive and negative primary antibodies...

Arrays of large-area, tip/tilt micromirrors for use in a high-contrast projector

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Reynald, Hoskinson , Stefan, Hampl , Boris, Stoeber
Arrays of two-degree of freedom analog micromirrors are designed for use within an high-contrast projector and fabricated using a multi-user MEMS fabrication process. We demonstrate a novel way of optimizing the tradeoffs between tilt angle and mirror size by subdividing the mirrors into smaller functional subsections that move synchronously. The mirror design employs multiple mirrors within a gimbal frame. The frame rotates around one axis, and each mirror within the frame rotates around a perpendicular axis, resulting in two-degree of freedom rotation. The design employs specific electrode shapes to allow one-layer connections. Using these fabricated mirrors, simultaneous actuation of mirrors...

Vibration Sensitivity Analysis of MEMS Vibratory Ring Gyroscopes

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Sang Won, Yoon , Sangwoo, Lee , Khalil, Najafi
This paper presents a detailed model for possible vibration effects on MEMS degenerate gyroscopes represented by vibratory ring gyroscopes. Ring gyroscopes are believed to be relatively vibration-insensitive because the vibration modes utilized during gyro operation are decoupled from the modes excited by environmental vibration. Our model incorporates four vibration modes needed to describe vibration-induced errors: two flexural modes (for gyro operation) and two translation modes (excited by external vibration). The four-mode dynamical model for ring gyroscopes is derived using Lagrange's equations. The model considers all elements comprising a ring gyroscope, namely the ring structure, the support-spring structures, and the electrodes...

Microcantilever sensors with embedded piezoresistive transistor read-out: design and characterization

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Pushpapraj, Singh , Jianmin, Miao , Shao, Lichun , Rama Krishna, Kotlanka , Woo-Tae, Park , ...
Microcantilevers are very effective tools in detecting of small amount of bio-species and chemicals. Recent advances in metal-oxide-semiconductor field effect transistor (MOSFET) as a transducer to detect the molecule binding-induced cantilever deflection has gained extensive attention due to its high sensitivity and direct compatibility with micro-electro-mechanical system (MEMS) sensors. In this paper, six different piezoresistive nMOSFET-embedded microcantilevers are designed and characterized to systematically study the impacts of different cantilever and transistor channel geometries on the device sensitivity. It is found that the amount of change in the drain current is the same range as reported in the literature. For point-loading...

Analysis of the environmental magnetic noise rejection by using two simple magnetoelectric sensors

22 August 2011, 20:51:37Go to full article
Publication year: 2011
Source: Sensors and Actuators A: Physical, In Press, Accepted Manuscript, Available online 22 August 2011
Y., Shen , J., Gao , L., Shen , D., Gray , J., Li , ...
We have evaluated the performance of a classical differential technique to reject magnetic or, in a lesser extent, the vibrational coherent noise sources sensed by two identical magnetoelectric (ME) laminated sensors with the help of a data logger. The signals of two ME sensors were directly subtracted given highly homogeneous external noise. Through a signal processing technique, the intrinsic noise of the ME sensor systems was obtained to be 20 pT/√Hz with a rejection factor of the external homogeneous noise sources of 20. The latter is mainly limited, as theoretical described, by the incoherent noise and discrepancy between the sensors....