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World Congress on Biosensors 2014
Biosensors 2014
Tuesday, 6 November 2012
Just Published: Sensors & Actuators B: Chemical
A new issue of this journal has just
been published. To see abstracts of the papers it contains (with links through
to the full papers) click here:
Publication year:
2012 Source:Sensors and Actuators B: Chemical, Volume 176 Jahangir
Ahmad Rather, Karolien De Wael Endocrine disruptors (EDCs) are environmental
pollutants that, once incorporated into an organism, affect the hormonal balance
of humans and various species. Its presence in environment is of great
importance in water quality related questions. The proposed method describes the
development of an accurate, sensitive and selective sensor for the detection of
bisphenol-A (BPA) and its treatment by green technology. A fullerene (C60)
fabricated electrochemical sensor was developed for the ultrasensitive detection
of BPA. The homemade sensor was characterized by scanning electron microscopy,
electrochemical impedance spectroscopy and chronocoulometry. The influence of
measuring parameters such as pH and C60 loading on the analytical performance of
the sensor was evaluated. Various kinetic parameters such as electron transfer
number (n); charge transfer coefficient (α); electrode surface area (A) and
diffusion coefficient (D) were also calculated. Under the optimal conditions,
the oxidation peak current was linear over the concentration range of 74nM to
0.23μM with the detection limit (LOD) of 3.7nM. The fabricated sensor was
successfully applied to the determination of BPA in wastewater samples and it
has promising analytical applications for the direct determination of BPA at
trace level.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Dong Woo Lee, Sang
Hyun Yi, Se Hoon Jeong, Bosung Ku, Jhingook Kim, Moo-Yeal Lee We have
developed a plastic pillar insert to facilitate miniaturized three-dimensional
(3D) cell cultures in 96-well plates by forming 3D hydrogel droplets containing
cells (about 1μL) on the tip of the pillar insert. Hemispherical 3D droplets
containing cells were formed simply by immersing the tip of the pillar insert
into a mixture of poly-L-lysine (PLL) and BaCl2 in a cell-encapsulation
apparatus, followed by dipping it into cell suspension in alginate. Compared to
traditional 3D cell culture platforms such as polymer scaffolds in 96 wells and
3D hanging drop plates, it allows us to easily change cell growth media or
expose 3D cells to reagents by immersing the tip of the pillar inserts in
different 96 wells filled with growth media or reagents. As a proof of concept,
A549 and PC9 cell lines from human non-small cell lung cancer (NSCLC) were grown
on the pillar insert and tested for cytotoxicity with Erlotinib. Both cells on
the tip of the pillar insert grew over time, forming 3D structures unlike
traditional 2D cell monolayer cultures and mimicking in vivo-like cellular
microenvironment. The number of cells in alginate droplets was linearly
proportional to the cell seeding density. The doubling time of A549 and PC9
cells were 15.9h and 16.1h, respectively, which were similar to those obtained
from traditional 2D cell cultures. IC50 values from A549 and PC9 cells exposed
to Erlotinib for 3 days were 15.2±7.0μM and 1.7±0.4nM, respectively, indicating
that PC9 cells with EGFR mutation are highly sensitive to Erlotinib.
Interestingly, the IC50 value of 3D PC9 cells grown on the pillar insert was 6
times lower than those obtained from 2D PC9 cells grown on the surface of
96-wells, whereas the IC50 value of 3D A549 cells were 5 times higher than those
from 2D A549 cells. The result may represent that A549 and PC9 cells grown on
the pillar insert are better mimicking what happens in humans.
Publication year:
2012 Source:Sensors and Actuators B: Chemical R.H. Zhang, X.T.
Zhang, S.M. Hu This H2S sensor, constructed from an Ag/Ag2S-based sensing
element and coupled with a Zr/ZrO2 reference electrode, and YSZ/HgO/Hg
electrode, had been tested for its potential response to H2S concentrations in
fluids at temperatures from 0°C to 400°C and pressures up to 25 or 33 MPa, and
is well suited for determining dissolved H2S concentrations in aqueous media at
elevated temperatures from 0°C to 400°C and at high pressures. The Ag/Ag2S
electrode is made of an Ag wire with an Ag2S film coating, which can be
pressurized and heated at high pressures and temperatures. The Nernstian
response of the Ag/Ag2S-YSZ/HgO/Hg cell potential to H2S concentrations at 400°C
and 25 MPa is described as. ΔE (V)=0.625+0. 0667 log mH2S. The Nernstian
response of the Ag/Ag2S−Zr/ZrO2 potential to H2S at 1°C and 33 MPa is described
as:. ΔE (V)=-0.261 - 0.02966 log mH2S.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Xianping Chen, Cell
K.Y. Wong, Cadmus A. Yuan, Guoqi Zhang Gas sensors fabricated with nanowires
as the detecting elements are powerful due to their many improved
characteristics such as high surface-to-volume ratios, ultrasensitivity, higher
selectivity, low power consumption, and fast response. This paper gives an
overview on the recent process of the development of nanotechnology and
nanowire-based gas sensors. The two basic approaches, top-down and bottom-up,
for synthesizing nanowires are compared. The conduction mechanisms, sensing
performances, configurations, and sensing principles of different nanowire gas
sensors and arrays are summarized and discussed. Meanwhile, an emerging
nanowires fabrication method and a self-powered nanowire pH sensor are
highlighted. The scientific and technological challenges in the field are
discussed at the end of the review.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Hongyu Ma, Enjie
Ding The pellistor (catalytic combustion) methane sensor is a typical sensor
with high working temperature. Historically, its heat dissipation via packaging
has not been fully considered for power minimization. A large amount of thermal
energy from the pellistor sensor is typically lost to the environment because of
the sensor's high sensing temperature and quasi-closed metal packaging. A
promising new approach to minimize the sensor power budget will be developed
when part of this heat energy is successfully retained. In this paper, we
explore this possibility by introducing hydrophobic silica aerogel as packaging
material owing to its excellent low thermal conductivity and high gas
permeability. Experimental results reveal that a significant power decrease of
approximately 30% and high sensitivity can be simultaneously achieved for the
traditional active pellistor methane sensor with thermal insulation-strengthened
packaging with silica aerogel.
Graphical abstract Highlights
Compared with the pellistor
packaged without silica aerogel, the pellistor packaged with silica aerogel
shows higher and sharp rising sensitivity at low power supply. What's more
interesting is that the power reduction is about 30% when taking the maximum
sensitivity of the pellistor without silica aerogel package as a reference. . ►
To reduce power consumption of pellistor methane sensor by means of improvement
of package thermal insulation, silica aerogel was introduced into the
conventional TO packaging of pellistor. ► Power declines at least about 30%
without sensitivity degradation relying on aerogel's super-thermal-isolation
capability. It is totally different with dimension miniaturization technology,
which is generally accompanied with unsatisfied sensitivity. ► Experiments
demonstrate that enhancing package thermal insulation would be a new attractive
power reduction approach for catalytic combustion gas sensors and even other
high-temperature gas sensor for meeting the demand of wireless sensor
net.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Carsten
Schwandt The presence of dissolved hydrogen in molten aluminium and its
alloys has a critical impact on the quality of cast aluminium components. The
quantitative analysis of hydrogen in these melts is therefore of major
importance in the aluminium industry. Research work conducted at the University
of Cambridge and subsequent development work performed in conjunction with an
industrial partner, have resulted in a novel, and now commercialised,
electrochemical hydrogen sensor for aluminium melts. The sensor operates in the
potentiostatic mode and relies on a proton-conducting solid electrolyte and a
metal/hydrogen-based solid reference electrode. This article summarises the main
steps of the underlying research and development programme, covering the actual
gas sensor, test measurements in gas phases under laboratory conditions, the
probe for molten metal application, and test measurements in aluminium melts
under industrial conditions.
Highlights
► A novel solid state electrochemical hydrogen
sensor has been developed. ► The sensor uses a ceramic proton conductor and a
solid metal/hydrogen reference. ► A refractory probe for use of the sensor in
aluminium melts has been developed. ► The novel analyser has performed
successfully in trials under industrial conditions. ► The research and
development programme has led to a commercialised product.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Jiaoliang Wang,
Liping Long, Dan Xie, Xiaofeng Song A rhodamine-based fluorescence chemsensor
bearing the 8-hydroxyquinoline unit is developed as a reversible turn-on
chemosensor for Cu2+. It exhibits a highly sensitive fluorescent
response toward Cu2+ in aqueous media with an 80-fold fluorescence
intensity enhancement under 10 equiv of Cu2+ added. This indicates
that the synthesized chemosensor effectively avoided the fluorescence quenching
for the paramagnetic nature of Cu2+ via its strong binding capability
toward Cu2+. The chemosensor Rh-Q exhibits a dynamic response range
for Cu2+ from 2×10−7 to 5×10−5 M, with a
detection limit of 0.19μM, and good selectivity for Cu2+ over other
heavy and transition metal (HTM) ions in Tris-HCl/EtOH (7: 3, v/v, pH 7.4). In
addition, the turn-on fluorescent change upon the addition of Cu2+ is
also applied in cell imaging.
Graphical abstract
Highlights
Graphical abstract ► We
report a new reversible Cu2+-Selective “Off-On” fluorescent
chemosensor. ► It exhibite reversibility, high sensitivity with a 80-fold
fluorescence enhancement. ► It exhibited a low detection limit of 0.19mM and
high selectivity for Cu2+. ► It is applied in vitro imaging of
Cu2+ in the living cells and potentially in vivo.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Xicheng Ma, Haiyan
Song, Congsheng Guan Uniform porous SnO2 hollow nanospheres with average
diameters of about 100-200nm have been reproducibly synthesized via a facile
template- and surfactant-free hydrothermal method, using hydrogen peroxide 30%
and stannous sulfate as precursors. The morphology, composition and structure of
the resultant products were characterized by X-ray diffraction (XRD), scanning
electron microscopy (SEM), transmission electron microscopy (TEM), energy
dispersive X-ray spectroscopy and nitrogen adsorption-desorption technique.
Experimental results demonstrated that the formation of these porous SnO2
nanostructures is ascribed to an interfacial oxidation-dehydration mechanism.
H2O2 usage has an important effect on both the morphology and purity of the
final products. The gas sensing properties of the as-prepared porous SnO2 hollow
nanospheres were investigated. By comparative gas sensing tests, the porous SnO2
hollow nanospheres exhibited superior gas sensing performances over commercial
SnO2 nanopowders toward some typical volatile organic compounds (VOCs), implying
their promising applications in gas sensors.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Federico Tasca,
Roland Ludwig, Lo Gorton, Riccarda Antiochia In this paper a new
third-generation amperometric biosensor for lactose determination is described.
The biosensor is based on the highly efficient direct electron transfer (DET)
between cellobiose dehydrogenase (CDH) from Phanerochate sordida (PsCDH) and
single walled carbon nanotubes (SWCNT). The SWNCTs were surface modified with
aryl diazonium salts of p-phenylenediamine (NH2-PD) and deposited on top of a
glassy carbon (GC) electrode. The PsCDHNH2-PD/SWCNT-GC biosensor showed very
efficient DET and exhibited an extraordinary high current density of
500μAcm−2 in a 5mM lactose solution at pH 3.5. The biosensor has a
detection limit for lactose of 0.5μM, a large linear range from 1 to 150μM
lactose and a high sensitivity (476.8nA μM−1 cm−2). It
shows also a fast response time (4 s), good reproducibility (RSD=1.75%) and good
stability (half-life 12 days). In addition, it is easy and simple to
manufacture, cheap because a low amount of enzyme is required and highly
selective, as no significant interference was observed. For these reasons, it
can represents a valid alternative to HPLC measurements for lactose
determination in milk and dairy products.
Publication year:
2012 Source:Sensors and Actuators B: Chemical Young Jun Kim, Md.
Mahbubur Rahman, Jae-Joon Lee Cadmium sulfide (CdS) quantum dots (QDs) were
coupled to an Au nanoimmunosensor on a quartz crystal microbalance (QCM) to form
the basis of an ultrasensitive and label-free sensor of annexin A3 (ANXA3), a
lung and prostate cancer biomarker protein. Polyclonal anti-ANXA3 antibody was
covalently immobilized on the CdS QDs, which had previously been functionalized
with carboxyl groups and bound to a cystamine self-assembled monolayer on the
Au/QCM. Frequency changes induced by the binding of ANXA3 to the anti-ANXA3 on
the probe's surface allowed the very sensitive detection of GST-ANXA3 with a
detection limit of 0.075±0.01ng/mL. The sensor could detect ANXA3 at 0.1ng/mL in
spiked human blood and urine samples in less than 15min without any interference
from other proteins.
Chemical is universal solvant used in various industrial purpose. for medical purpose it is ordered from bulk chemical suppliers because it get at low rates.
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