Solid Phase Extraction (SPE) is an effective method for sample preparation used in the most laboratories today. For nearly 30 years diverse SPE phases, packed in columns, cartridges and 96-well plates or as bulk material, are commercially available and will be expanded with newly developed materials almost every year. While at the beginning silica-based sorbents were predominant, polymers have entered into the market in the last years. More than 50 different types of SPE phases make a decision for the user not easy. Especially for RP phases, which can be used for multiple applications, the question is: “Silica or polymer RP phase?”
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