A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:Development and validation of an ion-pair RP-HPLC method for the determination of oligopeptide-20 in cosmeceuticals
07 July 2011, 21:18:41
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 7 July 2011
Panagiota, Papagianni , Athanasia, Varvaresou , Spyros, Papageorgiou , Irene, Panderi
Oligopeptide-20 is a growth-factor mimicking peptide used in cosmeceuticals. This article describes the development and validation of an ion-pair reversed-phase liquid chromatography method that allows, after liquid-liquid extraction, the quantification of oligopeptide-20 in cosmetic creams. Chromatographic separation was achieved on a cyanopropyl Hypersil analytical column (100×2.1mm i.d., 5μm particle size), using a mobile phase of acetonitrile- heptafluorobutyric acid (pH=2.5, 9.0mM) (70:30, v/v) containing 0.045% diethylamine at a flow rate of 0.50mLmin−1. Ultraviolet (UV) spectrophotometric detection at 225nm was used. The method had linear calibration curve over the range 1.35-4.95μgmL−1 for oligopeptide-20. The intra- and inter-day RSD values were less than...
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 7 July 2011
Panagiota, Papagianni , Athanasia, Varvaresou , Spyros, Papageorgiou , Irene, Panderi
Oligopeptide-20 is a growth-factor mimicking peptide used in cosmeceuticals. This article describes the development and validation of an ion-pair reversed-phase liquid chromatography method that allows, after liquid-liquid extraction, the quantification of oligopeptide-20 in cosmetic creams. Chromatographic separation was achieved on a cyanopropyl Hypersil analytical column (100×2.1mm i.d., 5μm particle size), using a mobile phase of acetonitrile- heptafluorobutyric acid (pH=2.5, 9.0mM) (70:30, v/v) containing 0.045% diethylamine at a flow rate of 0.50mLmin−1. Ultraviolet (UV) spectrophotometric detection at 225nm was used. The method had linear calibration curve over the range 1.35-4.95μgmL−1 for oligopeptide-20. The intra- and inter-day RSD values were less than...
Study on the Absolute Configuration of Levetiracetam via Density Functional Theory Calculations of Electronic Circular Dichroism and Optical Rotatory Dispersion
07 July 2011, 21:18:41
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 7 July 2011
Li, Li , Yi-Kang, Si
Theoretical calculation of chiroptical properties has been a powerful tool for the absolute configuration assignment of chiral compounds including synthetic drugs and natural products. In the present work, time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) and optical rotatory dispersion (ORD) were employed to investigate the absolute configuration of levetiracetam, which is a widely-used anticonvulsant drug. Nine conformers were generated by conformation search using the MMFF94 molecular mechanics force field, and the geometries were then optimized using the Becke 3-Lee-Yang-Parr (B3LYP) exchange-correlation functional. The population-averaged ECD spectrum was obtained by adding ECD spectrum of each conformer using...
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 7 July 2011
Li, Li , Yi-Kang, Si
Theoretical calculation of chiroptical properties has been a powerful tool for the absolute configuration assignment of chiral compounds including synthetic drugs and natural products. In the present work, time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) and optical rotatory dispersion (ORD) were employed to investigate the absolute configuration of levetiracetam, which is a widely-used anticonvulsant drug. Nine conformers were generated by conformation search using the MMFF94 molecular mechanics force field, and the geometries were then optimized using the Becke 3-Lee-Yang-Parr (B3LYP) exchange-correlation functional. The population-averaged ECD spectrum was obtained by adding ECD spectrum of each conformer using...
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