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Papers selected frm the latest issue:Planar solid phase extraction – a new clean-up concept in multi-residue analysis of pesticides by liquid chromatography–mass spectrometry
14 July 2011, 20:40:55
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 13 July 2011
Claudia, Oellig , Wolfgang, Schwack
Efficient clean-up is indispensable for preventing matrix effects in multi-residue analysis of pesticides in food by liquid and gas chromatography coupled to mass spectrometry. As a completely new approach, highly automated planar chromatographic tools were applied for powerful clean-up, called high-throughput planar solid phase extraction (HTpSPE). Thin-layer chromatography (TLC) was used to completely separate pesticides from matrix compounds and to focus them into a sharp zone, followed by extraction of the target zone by the TLC–MS interface. HTpSPE resulted in extracts nearly free of interference and free of matrix effects, as shown for seven chemically representative pesticides in four different...
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 13 July 2011
Claudia, Oellig , Wolfgang, Schwack
Efficient clean-up is indispensable for preventing matrix effects in multi-residue analysis of pesticides in food by liquid and gas chromatography coupled to mass spectrometry. As a completely new approach, highly automated planar chromatographic tools were applied for powerful clean-up, called high-throughput planar solid phase extraction (HTpSPE). Thin-layer chromatography (TLC) was used to completely separate pesticides from matrix compounds and to focus them into a sharp zone, followed by extraction of the target zone by the TLC–MS interface. HTpSPE resulted in extracts nearly free of interference and free of matrix effects, as shown for seven chemically representative pesticides in four different...
Zwitterionic-type hydrophilic interaction nano-liquidchromatography of complex and high mannose glycans coupled with electrospray ionisationhigh resolution time of flight mass spectrometry
13 July 2011, 20:42:22
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 12 July 2011
Lea, Mauko , Matthias, Pelzing , Sebastiaan, Dolman , Anna, Nordborg , Nathan A., Lacher , ...
In this study we describe a new method for rapid and sensitive analysis of reduced high mannose and complex glycans using zwitterionic-type hydrophilic interaction nano-liquid chromatography (nanoZIC-HILIC, 75μm I.D. x 150mm) coupled with high resolution nanoelectrospray ionisation time of flight mass spectrometry (nano ESI-TOF-MS).The retention of neutral glycans increases with increasing molecular weight and is higher for high mannose glycans than for complex-type glycans. The selectivity of ZIC-HILIC for sialylatedglycans differs from that for the neutral glycans and is believed to involve electrostatic repulsion; therefore charged glycans are eluted earlier than neutral glycans with comparable molecular weight. Due to the...
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 12 July 2011
Lea, Mauko , Matthias, Pelzing , Sebastiaan, Dolman , Anna, Nordborg , Nathan A., Lacher , ...
In this study we describe a new method for rapid and sensitive analysis of reduced high mannose and complex glycans using zwitterionic-type hydrophilic interaction nano-liquid chromatography (nanoZIC-HILIC, 75μm I.D. x 150mm) coupled with high resolution nanoelectrospray ionisation time of flight mass spectrometry (nano ESI-TOF-MS).The retention of neutral glycans increases with increasing molecular weight and is higher for high mannose glycans than for complex-type glycans. The selectivity of ZIC-HILIC for sialylatedglycans differs from that for the neutral glycans and is believed to involve electrostatic repulsion; therefore charged glycans are eluted earlier than neutral glycans with comparable molecular weight. Due to the...
Modelling of Elution-Extrusion Counter-current Chromatography using perfect replacement approach
13 July 2011, 20:42:22
Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 12 July 2011
Artak E., Kostanyan
Basing on the perfect replacement approach the equilibrium cell model is developed to describe the separation process in elution-extrusion countercurrent chromatography (EECCC). As is known, EECCC consists of three steps: classical elution, sweeping elution, and extrusion. The perfect replacement approach means that during sweeping elution step, the mobile phase contained in the column moves and interacts with the “old” stationary phase in the same mode as during the classical elution step; the “new” and “old” stationary phases do not mix; and after the contacting with the mobile phase the concentration of solutes in the “old” stationary phase remains constant and...
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 12 July 2011
Artak E., Kostanyan
Basing on the perfect replacement approach the equilibrium cell model is developed to describe the separation process in elution-extrusion countercurrent chromatography (EECCC). As is known, EECCC consists of three steps: classical elution, sweeping elution, and extrusion. The perfect replacement approach means that during sweeping elution step, the mobile phase contained in the column moves and interacts with the “old” stationary phase in the same mode as during the classical elution step; the “new” and “old” stationary phases do not mix; and after the contacting with the mobile phase the concentration of solutes in the “old” stationary phase remains constant and...
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