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Selected papers from the latest issue:Current instrumentation for aerosol mass spectrometry
18 July 2011, 22:26:40
Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Kari, Hartonen , Totti, Laitinen , Marja-Liisa, Riekkola
This review describes recently presented instrumental set-ups for aerosol mass spectrometry (AMS), most being suitable for in-situ analysis. AMS allows the analysis of atmospheric aerosol particles within a short time interval and without sample pretreatment, and it is less sensitive to artifact formation than conventional sampling and analytical techniques. Although a quantitative measure of total organic loading can be obtained with some AMS instruments, they currently give only limited information on specific compounds. When the ionization technique produces a large number of fragments for a compound, it becomes impossible to track the original compound. Moreover, at present, there is no...
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Kari, Hartonen , Totti, Laitinen , Marja-Liisa, Riekkola
This review describes recently presented instrumental set-ups for aerosol mass spectrometry (AMS), most being suitable for in-situ analysis. AMS allows the analysis of atmospheric aerosol particles within a short time interval and without sample pretreatment, and it is less sensitive to artifact formation than conventional sampling and analytical techniques. Although a quantitative measure of total organic loading can be obtained with some AMS instruments, they currently give only limited information on specific compounds. When the ionization technique produces a large number of fragments for a compound, it becomes impossible to track the original compound. Moreover, at present, there is no...
Recent advances in clinical microdialysis
18 July 2011, 22:26:40
Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter, Matzneller , Martin, Brunner
Clinical microdialysis (MD) is a minimally invasive sampling technique that offers selective, in-vivo measurement of free, active drug or biomolecule concentrations in human tissues and organs. From a regulatory perspective, MD can thus be seen as a suitable scientific tool that meets regulatory requirements for the study of tissue distribution or bioequivalence during drug development. From a clinical perspective, the use of MD in different applications has shown the potential to rationalize drug-dosing regimens and to influence clinical decision-making, although validation and correlation of MD-derived results with clinical response are required to promote routine clinical use of the technique. From...
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter, Matzneller , Martin, Brunner
Clinical microdialysis (MD) is a minimally invasive sampling technique that offers selective, in-vivo measurement of free, active drug or biomolecule concentrations in human tissues and organs. From a regulatory perspective, MD can thus be seen as a suitable scientific tool that meets regulatory requirements for the study of tissue distribution or bioequivalence during drug development. From a clinical perspective, the use of MD in different applications has shown the potential to rationalize drug-dosing regimens and to influence clinical decision-making, although validation and correlation of MD-derived results with clinical response are required to promote routine clinical use of the technique. From...
Solid-phase extraction and high-performance liquid chromatography mass spectrometry analysis of nitrosamines in treated drinking water and wastewater
18 July 2011, 22:26:40
Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
J.M., Boyd , S.E., Hrudey , S.D., Richardson , X.-F., Li
N-Nitrosamines, including N-dimethylnitrosamine (NDMA), were identified as chlorination byproducts in drinking water in 1989. Nitrosamines are known rodent carcinogens and probable human carcinogens, so that they have been considered disinfection byproducts (DBPs) of public health concern. Epidemiological studies show a potential association of consumption of chlorinated drinking water with an increased risk of bladder cancer. As small, relatively polar DBPs that often occur at low-ng/L concentrations in water, nitrosamines pose analytical challenges for accurate determination. Sample preparation (e.g., commonly used solid-phase extraction) plays a critical role in achieving reliable determination of nitrosamines at ng/L concentrations. Historically, gas chromatography (GC)-based techniques...
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
J.M., Boyd , S.E., Hrudey , S.D., Richardson , X.-F., Li
N-Nitrosamines, including N-dimethylnitrosamine (NDMA), were identified as chlorination byproducts in drinking water in 1989. Nitrosamines are known rodent carcinogens and probable human carcinogens, so that they have been considered disinfection byproducts (DBPs) of public health concern. Epidemiological studies show a potential association of consumption of chlorinated drinking water with an increased risk of bladder cancer. As small, relatively polar DBPs that often occur at low-ng/L concentrations in water, nitrosamines pose analytical challenges for accurate determination. Sample preparation (e.g., commonly used solid-phase extraction) plays a critical role in achieving reliable determination of nitrosamines at ng/L concentrations. Historically, gas chromatography (GC)-based techniques...
Modulators for comprehensive two-dimensional gas chromatography
18 July 2011, 22:26:40
Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter Quinto, Tranchida , Giorgia, Purcaro , Paola, Dugo , Luigi, Mondello
The analytical benefits of comprehensive two-dimensional gas chromatography (GC×GC) methods have been exploited and emphasized in the past two decades. The unexpectedly complex nature of many real-world samples amenable to GC analysis has been elucidated through the enhanced resolving power of GC×GC. Simple but fundamental devices, called modulators, enable continuous heart-cutting and re-injection, without which GC×GC analysis cannot be achieved. The present review focuses on the history (1991–2010), and present trends and future prospects for GC×GC modulation. We provide detailed descriptions and set out the advantages and the disadvantages of the most significant thermal and pneumatic modulators.
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter Quinto, Tranchida , Giorgia, Purcaro , Paola, Dugo , Luigi, Mondello
The analytical benefits of comprehensive two-dimensional gas chromatography (GC×GC) methods have been exploited and emphasized in the past two decades. The unexpectedly complex nature of many real-world samples amenable to GC analysis has been elucidated through the enhanced resolving power of GC×GC. Simple but fundamental devices, called modulators, enable continuous heart-cutting and re-injection, without which GC×GC analysis cannot be achieved. The present review focuses on the history (1991–2010), and present trends and future prospects for GC×GC modulation. We provide detailed descriptions and set out the advantages and the disadvantages of the most significant thermal and pneumatic modulators.
Climate-change impacts on water chemistry
18 July 2011, 22:26:40
Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Philippe, Quevauviller , Yoshio, Umezawa
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Philippe, Quevauviller , Yoshio, Umezawa
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