A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:Application of a liquid chromatography–tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice
09 August 2011, 21:27:31
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 9 August 2011
Silpa, Nuthalapati , Ping, Guo , Qingyu, Zhou , M.V. Ramana, Reddy , E. Premkumar, Reddy , ...
ON01910 is a small molecular weight benzyl styryl sulfone currently under investigation as a novel anticancer agent. The purpose of the investigation was to develop a sensitive and reproducible liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate levels of ON01910 in small amounts of five biological matrices; mouse plasma, feces, urine, normal brain and brain tumor. For all matrices, protein precipitation sample preparation was used that led to linear calibration curves with coefficients of determination greater than 0.99. The lower limit of quantitation (LLOQ) for all matrices was 5ng/ml except that for mouse urine which was 10ng/ml. The calibration standard...
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 9 August 2011
Silpa, Nuthalapati , Ping, Guo , Qingyu, Zhou , M.V. Ramana, Reddy , E. Premkumar, Reddy , ...
ON01910 is a small molecular weight benzyl styryl sulfone currently under investigation as a novel anticancer agent. The purpose of the investigation was to develop a sensitive and reproducible liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate levels of ON01910 in small amounts of five biological matrices; mouse plasma, feces, urine, normal brain and brain tumor. For all matrices, protein precipitation sample preparation was used that led to linear calibration curves with coefficients of determination greater than 0.99. The lower limit of quantitation (LLOQ) for all matrices was 5ng/ml except that for mouse urine which was 10ng/ml. The calibration standard...
Demonstration that methadone is being present in the exhaled breath aerosol fraction
09 August 2011, 21:27:31
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 9 August 2011
Olof, Beck , Sören, Sandqvist , Johan, Franck
Methadone has previously been found present in exhaled breath of methadone treated patients. This study aimed at studying if methadone is present in the aerosol fraction of exhaled breath and used different filter sampling techniques for that. Patients receiving methadone maintenance treatment were recruited for the study. Methadone was extracted from filters collecting methadone from exhaled breath using 2-propanol, methanol and ethyl acetate and measured using liquid-chromatography tandem mass-spectrometry. The limit of quantification was 5pg/sample and the intra-day imprecision and accuracy within 15%. The recovery of extracting methadone from filters was >90%. Two types of micro-particle filters were used in...
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 9 August 2011
Olof, Beck , Sören, Sandqvist , Johan, Franck
Methadone has previously been found present in exhaled breath of methadone treated patients. This study aimed at studying if methadone is present in the aerosol fraction of exhaled breath and used different filter sampling techniques for that. Patients receiving methadone maintenance treatment were recruited for the study. Methadone was extracted from filters collecting methadone from exhaled breath using 2-propanol, methanol and ethyl acetate and measured using liquid-chromatography tandem mass-spectrometry. The limit of quantification was 5pg/sample and the intra-day imprecision and accuracy within 15%. The recovery of extracting methadone from filters was >90%. Two types of micro-particle filters were used in...
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