A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:Simultaneous UFLC–ESI–MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: Application to pharmacokinetic studies in rats
24 August 2011, 21:50:57
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Junhui, Liu , Ying, Bi , Rong, Luo , Xia, Wu
The alkaloids from P. longum L showed protective effects on Parkinson's disease models in our previous study and piperine and piperlonguminine were the two main constituents in the alkaloids. The present study aimed at developing a rapid, sensitive, and accurate UFLC–ESI–MS/MS method and validating it for the simultaneous determination of piperine and piperlonguminine in rat plasma using terfenadine as the internal standard. The analytes and internal standard (IS) were extracted from rat plasma using a simple protein precipitation by adding methanol/acetonitrile (1: 1, v/v). A Phenomenex Gemini 3 u C18 column (20mm×2.00mm, 3 micrometer) was used to separate the analytes...
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Junhui, Liu , Ying, Bi , Rong, Luo , Xia, Wu
The alkaloids from P. longum L showed protective effects on Parkinson's disease models in our previous study and piperine and piperlonguminine were the two main constituents in the alkaloids. The present study aimed at developing a rapid, sensitive, and accurate UFLC–ESI–MS/MS method and validating it for the simultaneous determination of piperine and piperlonguminine in rat plasma using terfenadine as the internal standard. The analytes and internal standard (IS) were extracted from rat plasma using a simple protein precipitation by adding methanol/acetonitrile (1: 1, v/v). A Phenomenex Gemini 3 u C18 column (20mm×2.00mm, 3 micrometer) was used to separate the analytes...
Online extraction toxicological MS(n) screening system for serum and heparinized plasma and comparison of screening results between plasma and urine in the context of clinical data
24 August 2011, 21:50:57
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Daniel M., Mueller , Katharina M., Rentsch
Background: The two main matrices for screening are urine or serum and heparinized plasma. Whereas urine has the advantage of usually higher concentrations and longer detection windows, serum or heparinized plasma represent the current systemic drug exposure of a patient. Materials and Methods: An online extraction LC-MSn method using a MS2 and MS3 spectral library for the identification of substances has been developed and validated to screen serum and heparinized plasma. Extraction was performed by online turbulent flow chromatography under alkaline conditions. Chromatographic separation was achieved using a phenyl/hexyl column with acidic eluents. For detection, a linear ion trap, equipped with an APCI...
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
Daniel M., Mueller , Katharina M., Rentsch
Background: The two main matrices for screening are urine or serum and heparinized plasma. Whereas urine has the advantage of usually higher concentrations and longer detection windows, serum or heparinized plasma represent the current systemic drug exposure of a patient. Materials and Methods: An online extraction LC-MSn method using a MS2 and MS3 spectral library for the identification of substances has been developed and validated to screen serum and heparinized plasma. Extraction was performed by online turbulent flow chromatography under alkaline conditions. Chromatographic separation was achieved using a phenyl/hexyl column with acidic eluents. For detection, a linear ion trap, equipped with an APCI...
Gas-chromatography-tandem mass spectrometry assay for the quantification of four benzodiazepines and citalopram in eleven postmortem rabbit fluids and tissues, with application to animal and human samples
24 August 2011, 21:50:57
Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
N., Cartiser , F., Bévalot , C., Le Meur , Y., Gaillard , D., Malicier , ...
Pharmacokinetic studies and postmortem toxicological investigations require a validated analytical technique to quantify drugs on a large number of matrices. Three-step liquid/liquid extraction with online derivatization (silylation) ahead of analysis by gas chromatography-tandem mass spectrometry was developed and validated on rabbit specimens in order to quantify citalopram and 4 benzodiazepines (diazepam, nordazepam, oxazepam and temazepam) in 11 biological matrices (blood, urine, bile, vitreous humor, liver, kidney, skeletal muscle, brain, adipose tissue, bone marrow (BM) and lung). Since the 11 biological matrices came from the same animal species, full validation was performed on 1 matrix, bone marrow (considered the most complex),...
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 24 August 2011
N., Cartiser , F., Bévalot , C., Le Meur , Y., Gaillard , D., Malicier , ...
Pharmacokinetic studies and postmortem toxicological investigations require a validated analytical technique to quantify drugs on a large number of matrices. Three-step liquid/liquid extraction with online derivatization (silylation) ahead of analysis by gas chromatography-tandem mass spectrometry was developed and validated on rabbit specimens in order to quantify citalopram and 4 benzodiazepines (diazepam, nordazepam, oxazepam and temazepam) in 11 biological matrices (blood, urine, bile, vitreous humor, liver, kidney, skeletal muscle, brain, adipose tissue, bone marrow (BM) and lung). Since the 11 biological matrices came from the same animal species, full validation was performed on 1 matrix, bone marrow (considered the most complex),...
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