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Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry
29 August 2011, 00:22:24
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 27 August 2011
Xue, Qiao , Guan, Ye , Chun-fang, Liu , Zhi-xiang, Zhang , Qiang, Tu , ...
Eriocaulon buergerianum Koern. is the botanical source for the Chinese herbal medicine Gu-Jing-Cao. Other Eriocaulon species are also used as the same herb in local areas and are difficult to be differentiated. In order to improve the quality control of Gu-Jing-Cao, chemical constituents of E. buergerianum and adulterating species were analyzed by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MSn). The 70% methanol extracts were separated on a Zorbax SB-C18 column and eluted with acetonitrile-water (each containing 0.1% formic acid). The compounds were identified by ion-trap mass spectrometry in both positive and negative ion...
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 27 August 2011
Xue, Qiao , Guan, Ye , Chun-fang, Liu , Zhi-xiang, Zhang , Qiang, Tu , ...
Eriocaulon buergerianum Koern. is the botanical source for the Chinese herbal medicine Gu-Jing-Cao. Other Eriocaulon species are also used as the same herb in local areas and are difficult to be differentiated. In order to improve the quality control of Gu-Jing-Cao, chemical constituents of E. buergerianum and adulterating species were analyzed by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MSn). The 70% methanol extracts were separated on a Zorbax SB-C18 column and eluted with acetonitrile-water (each containing 0.1% formic acid). The compounds were identified by ion-trap mass spectrometry in both positive and negative ion...
UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices
26 August 2011, 21:34:23
Publication year: 2011
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 26 August 2011
Antoine, Lévèques , Lucas, Actis-Goretta , Maarit J., Rein , Gary, Williamson , Fabiola, Dionisi , ...
Hesperidin (hesperetin-7-O-rutinoside), a flavonoid affecting vascular function, is abundant in citrus fruits and derived products such as juices. After oral administration, hesperidin is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside, the glucoside group is further cleaved and the resulting hesperetin is absorbed and metabolized. Flavanones have a chiral carbon generating (R)- and (S)-enantiomers, with potentially different biological activities. A rapid UPLC-MS/MS method for the analysis of (R)- and (S)-hesperetin enantiomers in human plasma and urine was developed and validated. Biological matrices were incubated with β-glucuronidase/sulfatase, and hesperetin was isolated by solid-phase extraction using 96-well plate mixed-mode cartridges having reversed-phase and...
Highlights: ► Hesperidin (hesperetin-7-O-rutinoside) is a flavonoid abundant in citrus fruits and derived products such as juices. ► When hesperidin is consumed by humans, the rhamnose part of the rutinoside group is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside and hesperetin. ► Hesperidin exhibits potential health benefits. ► We developed and validated a rapid analytical method for accurate quantification of hesperetin and hesperetin enantiomers in human urine and plasma samples within a clinical trial.
Source: Journal of Pharmaceutical and Biomedical Analysis, In Press, Accepted Manuscript, Available online 26 August 2011
Antoine, Lévèques , Lucas, Actis-Goretta , Maarit J., Rein , Gary, Williamson , Fabiola, Dionisi , ...
Hesperidin (hesperetin-7-O-rutinoside), a flavonoid affecting vascular function, is abundant in citrus fruits and derived products such as juices. After oral administration, hesperidin is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside, the glucoside group is further cleaved and the resulting hesperetin is absorbed and metabolized. Flavanones have a chiral carbon generating (R)- and (S)-enantiomers, with potentially different biological activities. A rapid UPLC-MS/MS method for the analysis of (R)- and (S)-hesperetin enantiomers in human plasma and urine was developed and validated. Biological matrices were incubated with β-glucuronidase/sulfatase, and hesperetin was isolated by solid-phase extraction using 96-well plate mixed-mode cartridges having reversed-phase and...
Highlights: ► Hesperidin (hesperetin-7-O-rutinoside) is a flavonoid abundant in citrus fruits and derived products such as juices. ► When hesperidin is consumed by humans, the rhamnose part of the rutinoside group is hydrolyzed by the colonic microbiota producing hesperetin-7-O-glucoside and hesperetin. ► Hesperidin exhibits potential health benefits. ► We developed and validated a rapid analytical method for accurate quantification of hesperetin and hesperetin enantiomers in human urine and plasma samples within a clinical trial.
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