This study evaluates Near-Infrared (NIR) analysis of tablets nominally containing 4 mg of chlorpheniramine maleate (CPM) and 10 mg of phenylephrine hydrochloride (PE-HCl) per dose. The data showed promising results that could relieve laboratory workload and bring analysis closer to real time for process monitoring. Ten tablets could be analyzed in less than 3 min. The NIR assay for the determination of tablets' CU is a fast and accurate means of monitoring tablets that could be used for production and is consistent with FDA's PAT initiative.
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