Selected papers from the latest issue:
The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
01 February 2012, 22:09:29
Publication year: 2012
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 1 February 2012
Martin Vordermeier, Gobena Ameni, Stefan Berg, Richard Bishop, Brian D. Robertson, ...
Bovine tuberculosis in domestic livestock such as cattle is an economically important disease with zoonotic potential, particularly in countries with emerging economies. We discuss the findings of recent epidemiological and immunological studies conducted in Ethiopia on host susceptibility differences between native zebu and the exotic Holstein–Friesian cattle that are increasingly part of the Ethiopian National herd, due to the drive to increase milk yields. These findings support the hypothesis that native Zebu cattle are more resistant to bovine tuberculosis. We also summarise the results of experimental infections that support the epidemiological data, and of laboratory experiments that suggest a role for the innate immune response, and in particular interleukin-6, in the outcome of bovine tuberculosis infection.
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 1 February 2012
Martin Vordermeier, Gobena Ameni, Stefan Berg, Richard Bishop, Brian D. Robertson, ...
Bovine tuberculosis in domestic livestock such as cattle is an economically important disease with zoonotic potential, particularly in countries with emerging economies. We discuss the findings of recent epidemiological and immunological studies conducted in Ethiopia on host susceptibility differences between native zebu and the exotic Holstein–Friesian cattle that are increasingly part of the Ethiopian National herd, due to the drive to increase milk yields. These findings support the hypothesis that native Zebu cattle are more resistant to bovine tuberculosis. We also summarise the results of experimental infections that support the epidemiological data, and of laboratory experiments that suggest a role for the innate immune response, and in particular interleukin-6, in the outcome of bovine tuberculosis infection.
Introduction
31 January 2012, 00:28:56
Publication year: 2012
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 29 January 2012
Simon M. Barratt-Boyes
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 29 January 2012
Simon M. Barratt-Boyes
Functional analysis and induction of four novel goose (Anser cygnoides) avian β-defensins in response tosalmonella enteritidisinfection
29 January 2012, 03:22:10
Publication year: 2012
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 28 January 2012
Deying Ma, Caiyuan Zhou, Mingyue Zhang, Zongxi Han, Yuhao Shao, ...
In the current study, four novel avian β-defensins (AvBDs) (AvBD2, 5, 9, and 10) were identified in tissues from the Chinese goose (Anser cygnoides). The antibacterial activity of the AvBDs showed that all of these AvBDs exhibited antibacterial activity against most of the bacteria investigated (P < 0.01). In addition, antibacterial activity of all of the AvBDs againstStaphylococcus aureusandPasteurella multocidadecreased significantly or was completely abolished at 150 mM NaCl (P < 0.01). None of the AvBDs showed hemolytic activity. AvBD2 and AvBD10 were expressed widely, whereas AvBD5 and AvBD9 mRNAs were expressed in a limited number of geese tissues. AvBD9 was significantly induced in some immune tissues from geese afterSalmonella enteritidisinfection. The others were significantly upregulated in small intestine and some immune tissues of the geese (P < 0.01). The present results suggest that the AvBDs are part of the host defense mechanism of the goose.
Source: Comparative Immunology, Microbiology and Infectious Diseases, Available online 28 January 2012
Deying Ma, Caiyuan Zhou, Mingyue Zhang, Zongxi Han, Yuhao Shao, ...
In the current study, four novel avian β-defensins (AvBDs) (AvBD2, 5, 9, and 10) were identified in tissues from the Chinese goose (Anser cygnoides). The antibacterial activity of the AvBDs showed that all of these AvBDs exhibited antibacterial activity against most of the bacteria investigated (P < 0.01). In addition, antibacterial activity of all of the AvBDs againstStaphylococcus aureusandPasteurella multocidadecreased significantly or was completely abolished at 150 mM NaCl (P < 0.01). None of the AvBDs showed hemolytic activity. AvBD2 and AvBD10 were expressed widely, whereas AvBD5 and AvBD9 mRNAs were expressed in a limited number of geese tissues. AvBD9 was significantly induced in some immune tissues from geese afterSalmonella enteritidisinfection. The others were significantly upregulated in small intestine and some immune tissues of the geese (P < 0.01). The present results suggest that the AvBDs are part of the host defense mechanism of the goose.
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