Asynt has supplied the Wilson Structural Chemistry Research Group at the
University of Bath (Bath, UK) with a custom DrySyn heating block system.
The adapted DrySyn system, designed by Asynt in conjunction with the University
of Bath, is being used to help simplify and accelerate development of
crystallisation methodology to selectively control polymorph formation, and to
generate multi-component crystals with favourable target physical properties such
as optical effects, solubility and porosity.
Control of the solid form of crystalline materials is desirable in many
industrial sectors including the pharmaceutical and agrichemical industries
where the production of different polymorphs, co-crystals or salts are known to
affect significantly the physical properties of target active
ingredients. There are many factors known to affect crystal formation
including choice of solvent or solvents, temperature of crystallisation and the
presence of additives or additional component in the crystallisation process.
Dr Lynne Thomas - a research fellow at the University of Bath commented
"Temperature fluctuations in particular are known both to induce
crystallisation and potentially can act as a switch controlling which stable
crystalline form is obtained. Careful temperature control of samples
crystallising is therefore of critical importance in this field, as is a
heavily parallel approach to allow systematic investigation of the effect of
crystallisation conditions on solid form. The number of potential
temperature and solvent combinations thus makes screening conditions through a
parallel approach to temperature controlled crystallisation much more
efficient, and in many cases essential".
Dr Thomas added "In collaboration with Asynt, we have designed and
installed custom heating blocks in our Crystallisation laboratory to optimise
the temperature controlled space on each DrySyn heating block. The novel
adapted DrySyn heating block, which enables precise control of 19
crystallisations in parallel, has proven its ability to increase the
flexibility and speed of low to medium throughput crystallisation
experiments".
For further information on adapted heating blocks for parallel crystallisation
please contact Asynt on +44-1638-781709 or sales@asynt.com.
For further information on the Wilson Research Group at the University of Bath
please visit http://people.bath.ac.uk/lt302/group/index.htm
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