Thermo Fisher Scientific Inc.,
the world leader in serving science, has published a white paper entitled “Optimizing
mobile phase solvent purity for LC/MS.” Enhanced sensitivity and mass
accuracy in liquid chromatography/mass spectroscopy (LC/MS) is essential when
analytes are found in trace amounts. Purity is a crucial consideration when
selecting appropriate solvents for use in such analyses, where background noise
must be minimal. Optimizing the quality of mobile phase solvents can contribute
to improving the chromatographic or mass spectroscopic properties of the
analyte, as well as the overall detection limits of the instrument system. The
whitepaper highlights the low mass background, metal ion content, contamination
and LC/UV response, using diode array detection, that is possible when using
the Fisher Chemical Optima LC/MS solvent range instead of other solvent brands.
Examining LC/MS solvents offered
by seven companies, including Thermo Fisher, the white paper presents
comparative chromatographic data from four different advanced LC/MS
instruments. Data collected includes mass baseline, signal intensity,
contamination by PEG and plasticizers, and metal ion content, all of which
impact on the ease of MS interpretation. This data suggests that the Optima
LC/MS solvent range is best for mobile phase purity.
Optima LC/MS solvents are
manufactured and packaged using proprietary techniques to ensure exceptionally low
metal ion content and minimal MS background noise. They also offer lot-to-lot
consistency and extended column life due to low residue levels, setting the
standard of excellence for consistent, reproducible performance in the mobile
phase of advanced LC/MS systems.
The white paper can be downloaded at: http://www.thermo.com/eThermo/CMA/PDFs/Various/File_52953.pdf.
For more information on the Optima LC/MS
reagents and other Fisher Chemical products, please visit www.acros.com or contact a local Fisher
Chemical distributor.
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