World Congress on Biosensors 2014

World Congress on Biosensors 2014
Biosensors 2014

Wednesday 23 January 2013

Just Published: Trends in Analytical Chemistry


A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:
Selected papers from the latest issue:

Synthesis and applications of functionalized magnetic materials in sample preparation

22 January 2013, 14:39:26
Available online 17 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

Functionalized magnetic materials (FMMs) have been widely used in analytical chemistry. For sample preparation, FMMs show many advantages including easy surface modification, easy operation and high extraction efficiency. In this review, we describe the recent advances in FMMs in sample preparation. We first discuss their synthesis and characterization. We then focus on their application to enrichment of biological macromolecules of the proteome and contaminants in foods. Finally, we outline the prospects for FMMs in sample preparation.

Highlights

► We discuss synthesis and characterization of functionalized magnetic materials. ► Functionalized magnetic materials applied to biological macromolecules of proteome. ► Applications of functionalized magnetic materials to food-contaminant analysis.

Molecularly-imprinted polymers as a versatile, highly selective tool in sample preparation

22 January 2013, 14:39:26
Available online 15 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

Sample preparation is still considered the bottleneck of the whole analytical process. In this regard, improvement in selectivity during extraction and/or subsequent clean-up of sample extracts is an area of intense research activity. One of the most versatile, promising options is to incorporate molecularly-imprinted polymers (MIPs) into sample preparation. MIPs are tailor-made, stable polymers with molecular recognition abilities, so that they are excellent materials for providing selectivity in sample preparation. This review describes the use of MIPs in sample preparation, including solid-phase extraction, and corresponding recent improvements, and their recent incorporation into other extraction techniques (e.g., solid-phase microextraction, matrix-solid phase dispersion and stir-bar sorptive extraction). It discusses the advantages and the drawbacks of each methodology, and the future expected trends.

Highlights

► Critical review of using molecularly-imprinted polymers (MIPs) in sample preparation. ► Molecularly-imprinted polymers (MIPs) used in SPE, SPME and SBSE. ► Molecularly-imprinted polymers (MIPs) used with MSPD and liquid membranes.

Time-resolved mass spectrometry

22 January 2013, 14:39:26
Available online 12 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

Mass spectrometry (MS) offers advantages over conventional spectroscopic assays because it enables structural determination of reactants while preserving temporal resolution. The ability to detect short-lived reaction intermediates or labile metabolites makes time-resolved MS (TRMS) measurements an enabling tool for studies of chemical reactions, chemical kinetics and biochemical dynamics. High temporal resolution requires careful optimization of the interface, which would enable quenching of the chemical process, ionization and rapid transfer of the analytes into the mass analyzer. We review recent advances in TRMS, and outline the prospects for future developments and applications.

Highlights

► Mass spectrometry determines reactant structure while preserving temporal resolution. ► High temporal resolution requires careful optimization of the interface. ► Time-resolved mass spectrometry has already found a number of applications. ► Studies include reaction kinetics and mechanism, and protein folding. ► Studies include biochemical processes in vitro and in vivo.

Analytical challenges in breath analysis and its application to exposure monitoring

22 January 2013, 14:39:26
Available online 11 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

There is an increasing interest in the use of breath analysis for monitoring human physiology and exposure to toxic substances or environmental pollutants. This review focuses on the current status of the sampling procedures, collection devices and sample-enrichment methodologies used for exhaled breath-vapor analysis. We discuss the different parameters affecting each of the above steps, taking into account the requirements for breath analysis in exposure assessments and the need to analyze target compounds at sub-ppbv levels. Finally, we summarize the practical applications of exposure analysis in the past two decades.

Highlights

► Common containers for sampling collection are compared and discussed. ► Advantages and disadvantages of SPME and sorbent trap methods are discussed. ► Losses associated to the use of gas sampling bags are discussed. ► The use of a new methodology based on needle traps is presented. ► A summary is made of the applications in exposure analysis in the past two decades.

Terahertz spectral analysis

22 January 2013, 14:39:26
Available online 8 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

Terahertz (THz) spectroscopy is a well-established technique, and recent progress in technology demonstrated that it is useful for fundamental research and industrial applications. Applications (e.g., imaging, non-destructive testing, and quality control) are about to be transferred to industry, following improvements derived from basic research. Since chemometrics is routinely applied to infrared spectroscopy, we discuss the advantages of applying chemometrics to THz spectroscopy. We illustrate different analytical procedures. We conclude that advanced data processing is the key to validating THz spectroscopy as a reliable, routine analytical technique.

Highlights

► We discuss the advantages of using chemometrics in terahertz spectroscopy. ► We demonstrate the complementary nature of information from terahertz spectroscopy. ► Chemometrics is key to terahertz spectroscopy being a reliable analytical technique.

Nanoporous anodic aluminum oxide for chemical sensing and biosensors

22 January 2013, 14:39:26
Available online 3 January 2013
Publication year: 2013
Source:TrAC Trends in Analytical Chemistry

Nanoporous anodic aluminum oxide (AAO) has become one of the most popular materials with potential applications in numerous areas, including molecular separation, catalysis, energy generation and storage, electronics, photonics, sensing, drug delivery, and template synthesis. The fabrication of AAO is based on simple, cost-effective self-ordering anodization of aluminum, which yields vertically-aligned, highly-ordered nanoporous structures. Due to its unique optical and electrochemical properties, nanoporous AAO has been extensively explored as a platform for developing inexpensive, portable sensing and biosensing devices. This article reviews AAO-based sensing and biosensing technologies, highlighting key examples of different detection concepts and device performance. We conclude with a perspective on the exciting opportunities for further developments in this research field.

Highlights

► The structure, fabrication and properties of nanoporous alumina are described. ► Nanoporous alumina possess many advantages for sensing and biosensing. ► Recent advances in optical sensors and biosensors are highlighted. ► Recent developments of electrochemical sensors and biosensors are presented.

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