A new issue of this journal has just
been published. To see abstracts of the papers it contains (with links through
to the full papers) click here:
Selected
papers from the latest issue:
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2.
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Simultaneous
quantitation of azole antifungals, antibiotics, imatinib, and raltegravir in
human plasma by two-dimensional high-performance liquid chromatography–tandem
mass spectrometry Original Research Article
Pages 1-9 Jean-François Jourdil, Julia Tonini, Françoise Stanke-Labesque
Highlights
► Fast and
simultaneous quantitation of different classes of drugs in human plasma. ►
Simple sample preparation step by protein precipitation. ► LC–MS/MS analysis
with online sample clean up. ► Efficient tool for optimization of laboratory
resource utilization. |
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3.
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Determination
of gemcitabine and its metabolite in extracellular fluid of rat brain tumor
by ultra performance liquid chromatography–tandem mass spectrometry using
microdialysis sampling after intralesional chemotherapy Original Research Article
Pages 10-19 Ying Sun, Daoquan Tang, Hui Chen, Fan Zhang, Bin Fan, Bei Zhang, Shaoying Fang, Qian Lu, Yaqin Wei, Jiale Yin, Xiaoxing Yin
Highlights
►
Gemcitabine is effective in the treatment of malignant gliomas. ►
Gemcitabine's metabolite dFdU may contribute to gemcitabine's toxicity. ► A
microdialysis technique with UPLC–MS/MS method was developed. ► All the
validation data are within the required limits. ► The method was applied to
determine gemcitabine and dFdU in rat tumor. |
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4.
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A
liquid chromatography and tandem mass spectrometry method for the
determination of potential biomarkers of cardiovascular disease Original Research Article
Pages 20-29 Sylwia Magiera, Irena Baranowska, Jacek Kusa, Jacek Baranowski
Highlights
►
Development of HPLC–ESI-MS/MS method for the determination of potential
biomarkers. ► Optimization of the MS/MS and chromatographic conditions. ►
Solid-phase extraction procedure for human urine sample cleanup. ► This
method could be useful in the detection of heart failure before symptoms of the
disease. |
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5.
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Simultaneous
determination of quinocetone and its major metabolites in chicken tissues by
high-performance liquid chromatography tandem mass spectrometry Original Research Article
Pages 30-37 Yan Yong, Yahong Liu, Limin He, Lixiao Xu, Yaping Zhang, Binghu Fang
Highlights
►
Quinocetone and its four metabolites. ► Chicken muscle, liver, kidney and fat
tissues. ► A rapid and sensitive LC–MS/MS method is firstly developed. ► The
elimination curves of quinocetone and its metabolites are obtained. |
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6.
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Development
and validation of an assay for the simultaneous determination of zidovudine,
abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma
using liquid chromatography–tandem mass spectrometry Original Research Article
Pages 43-51 W. Kromdijk, S.A. Pereira, H. Rosing, J.W. Mulder, J.H. Beijnen, A.D.R. Huitema
Highlights
►
Quantification of nucleoside and nucleotide analogs in plasma using
HPLC–MS/MS. ► Zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and
ribavirin. ► Validation of the assay according to FDA guidelines. |
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7.
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A
fast and reliable reversed phase high performance liquid chromatography
method for simultaneous determination of selected anti-retroviral and
lumefantrine in human plasma
Original Research
Article
Pages 52-60 Betty Maganda, Olivier Heudi, Agnes Cortinovis, Franck Picard, Olivier Kretz, Omary Minzi
Highlights
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Development and validation of fast, reproducible, and accurate LC-UV method.
► Simultaneous determination Nevirapine, Efavirenz and Lumefantrine in human
plasma. ► The method is applicable to clinical samples from malaria and HIV
patients. ► The method is easy to implement in laboratories with limited
resources. |
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8.
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Sodium
citrate and potassium phosphate as alternative adsorption buffers in
hydrophobic and aromatic thiophilic chromatographic purification of plasmid
DNA from neutralized lysate
Original Research
Article
Pages 67-74 Nemailla Bonturi, Vanessa Soraia Cortez Oliveira Radke, Sônia Maria Alves Bueno, Sindélia Freitas, Adriano Rodrigues Azzoni, Everson Alves Miranda
Highlights
►
Alternative salts can be used in pDNA HIC and TAC as buffer systems. ► pDNA
purification with HIC and TAC can be done directly with neutralized lysate. ►
Mercaptopyrimidine agarose/sodium citrate system recovered 91.1% of the pDNA.
► Mercaptopyrimidine agarose/potassium phosphate system resulted in 98.8%
pDNA purity. |
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Short Communications
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9.
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Rapid
determination of sumatriptan in human plasma by ultra performance liquid
chromatography–tandem mass spectrometry and its application to clinical
pharmacokinetic study
Pages 38-42 Jeong Ju Seo, Jeonghyeon Park, Min Ho Bae, Mi-sun Lim, Sook Jin Seong, Joomi Lee, Sung Min Park, Hae Won Lee, Young-Ran Yoon
Highlights
► An
U-HPLC–MS/MS analysis method for the quantification of sumatriptan was
developed and validated using human plasma. ► This analysis method has been
successfully validated in the 0.5–50ng/mL calibration range. ► The assay
method precision was within 11.8%, and accuracy was between 97.4 and 102.9%.
► The developed and validated method was successfully applied to a
pharmacokinetic study of sumatriptan. |
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10.
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Validation
of an efficient LC-microdialysis method for gemifloxacin quantitation in
lung, kidney and liver of rats
Pages 62-66 Bibiana Verlindo de Araújo, João Victor Laureano, Lauren Dockhorn Grünspan, Teresa Dalla Costa, Leandro Tasso
Highlights
► An
efficient method for quantitation of unbound gemifloxacin concentrations is
reported. ► Gemifloxacin was successfully determined in kidney, lung and
liver of rats. ► Gemifloxacin unbound tissue concentrations were kidney>liver>lung. |
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11.
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Determination
of ginsenoside Rc in rat plasma by LC–MS/MS and its application to a
pharmacokinetic study
Pages 75-78 Yang Chu, Hong-chao Zhang, Shu-ming Li, Jun-mei Wang, Xiang-yang Wang, Wei Li, Lan-lan Zhang, Xiao-hui Ma, Shui-ping Zhou, Yong-hong Zhu, Chang-xiao Liu
Highlights
► It is
the first analytical method (LC–MS/MS) for determining ginsenoside Rc in rat.
► It is the first report of bioavailability and pharmacokinetics of
ginsenoside Rc. ► It provides the necessary information for the further
investigation of ginseng. |
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Erratum
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12.
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Erratum
to “Novel multi-mode ultra performance liquid chromatography–tandem mass
spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin
in human plasma” [J. Chromatogr. B 879 (2011) 1056–1062]
Pages 61 Drew R. Jones, Gunnar Boysen, Grover P. Miller |
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