Just Published: Analytica Chimica Acta

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5216

Selected papers from the latest issue:

DETERMINATION OF STEROID HORMONES IN BIOLOGICAL AND ENVIRONMENTAL SAMPLES USING GREEN MICROEXTRACTION TECHNIQUES: AN OVERVIEW

28 July 2011, 21:55:20

Publication year: 2011
Source: Analytica Chimica Acta, In Press, Accepted Manuscript, Available online 28 July 2011
Jana, Aufartová , Cristina, Mahugo-Santana , Zoraida, Sosa-Ferrera , José Juan, Santana-Rodríguez , Lucie, Nováková , ...
Residues of steroid hormones have become a cause for concern because they can affect the biological activity of non-target organisms. Steroid hormones are a potential risk for wildlife and humans through the consumption of contaminated food or water. Their determination requires extraction and clean-up steps, prior to detection, to reach low concentration levels. In recent years, a great effort has been made to develop new analytical methodologies, such as microextraction techniques, that reduce environmental pollution. Researchers have modified old methods to incorporate procedures that use less-hazardous chemicals or that use smaller amounts of them. They are able to do direct...
 Highlights: ► Green analytical methodologies for the determination of hormones in environmental samples are reported. ► Applications in sorptive-microextraction modes such as MIPs, in-tube SPME, SBSE and MEPS are described. ► Liquid-phase microextraction approaches like HFME and SD-LPME are also included. ► Advantages and disadvantages are given for each technique. The need for automation, the use of experimental designs and new solvents are discussed.

Surface-enhanced Raman scattering detection of cholinesterase inhibitors

28 July 2011, 21:55:20

Publication year: 2011
Source: Analytica Chimica Acta, In Press, Accepted Manuscript, Available online 28 July 2011
Zvi, Liron , Adi, Zifman , Vered, Heleg-Shabtai
A new sensitive surface-enhanced Raman scattering (SERS) assay for detection of cholinesterase inhibitors such as organophosphorous pesticides using silver colloidal nanoparticles was developed and optimized. Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. Variation in enzyme activity due to inhibition was measured from changes in intensity of a characteristic peak (772cm−1) of the SERS spectrum that was directly correlated with the concentration of produced thiocholine. The method was demonstrated for the detection of paraoxon as reference AChE inhibitor. Limit of detection of paraoxon for five min...
 Highlights: ► A new sensitive surface-enhanced Raman scattering (SERS) assay for detection of cholinesterase inhibitors such as organophosphorous pesticides using silver colloidal nanoparticles was developed and optimized. ► Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. ► The method was demonstrated for the detection of paraoxon as reference AChE inhibitor.

A robust method for speciation, separation and photometric characterization of all [PtCl6-nBrn]2-(n=0–6) and [PtCl4-nBrn]2− (n=0–4) complex anions by means of ion-pairing RP-HPLC coupled to ICP-MS/OES, validated by high resolution 195Pt NMR spectroscopy

28 July 2011, 21:55:20

Publication year: 2011
Source: Analytica Chimica Acta, In Press, Accepted Manuscript, Available online 28 July 2011
Pieter-Hugo, van Wyk , Wilhelmus J., Gerber , Klaus R., Koch
A robust reversed phase ion-pairing RP-HPLC method has been developed for the unambiguous speciation and quantification of all possible homoleptic and heteroleptic octahedral platinumIV[PtCl6-nBrn]2− (n=0–6) as well as the corresponding platinumII [PtCl4-nBrn]2− (n=0–4) complex anions using UV/Vis detection. High resolution 195Pt NMR in more concentrated solutions of these PtII/IV complexes (≥ 50mM) served to validate the chromatographic peak assignments, particularly in the case of the possible stereoisomers of PtIV/II complex anions. By means of IP-RP-HPLC coupled to ICP-MS or ICP-OES it is possible to accurately determine the relative concentrations of all possible PtII/IV species in these solutions, which allows for...
 Highlights: ► Ion-pairing RP-HPLC separation of all homoleptic and heteroleptic [PtCl6-nBrn]2− (n=0–6) and [PtCl4-nBrn]2− (n=0–4) ► High resolution 195Pt NMR validation of chromatographic peak assignments, including stereo-isomers of PtIV/II complexes ► IP-RP-HPLC coupled to ICP-MS/OES gives accurate concentrations of all PtII/IV species in aqueous acidic solutions ► UV/Vis photometric properties (λmax and ɛ) of all [PtCl6-nBrn]2− and [PtCl4-nBrn]2− complexes determined for future use

A Carbohydrate Modified Fluoride Ion Sensor and Its Applications

28 July 2011, 21:55:20

Publication year: 2011
Source: Analytica Chimica Acta, In Press, Accepted Manuscript, Available online 27 July 2011
Guohua, Wei , Junxia, Yin , Xing, Ma , Shouyi, Yu , Dongbin, Wei , ...
A new fluorescent probe for the detection of F− (TBA+ and Na+ salts) has been developed, which is based on a desilylation triggered chromogenic reaction in water. This probe exhibits excellent F− ion selectivity as well as significant color changes visible to the naked eye at the concentration of 1.5mg/L, the WHO recommended level of F− ions in drinking water. This new carbohydrate modified probe can be used directly in aqueous medium without using organic co-solvents. Furthermore, the probe presents high sensitivity and selectivity for the imaging of F− ions in HepG2 cells.

JEOL Unveils New High Throughput, Automated TEM for Nano-analysis

A new 200kV Transmission Electron Microscope from JEOL delivers high throughput nano-analysis for process and quality control of mass produced semiconductor and materials samples. The multi-function JEOL JEM-2800 features high resolution imaging in TEM, STEM, and SE modes; ultrasensitive elemental mapping with a large angle Energy Dispersive Spectrometer (EDS); Electron Energy Loss Spectroscopy (EELS) for chemical analysis; critical dimension analysis; tomography; and in situ observation of samples. The all-new TEM functions without use of the traditional fluorescent screen on the electron column.

The JEM-2800 speeds specimen observation through fully automatic functions including adjustment of focus, astigmatism, contrast, brightness, crystal zone axis alignment, and height. Switching between analysis modes is seamless, and quick data collection shortens turnaround time between samples. An operator navigation system and on-screen operating guide make the JEM-2800 a high throughput, user-friendly TEM for any skill level.

Additional features and key specifications of the JEM-2800 include a Schottky field-emission electron gun, highly stable eucentric side-entry goniometer stage, a magnification range of 100X to 150,000,000X using STEM, 0.1nm TEM resolution and 0.20nm BF/DF STEM resolution.

The JEM-2800 is JEOL’s latest addition to its comprehensive lineup of 100-300kV TEMs and most recently the ARM200F atomic resolution TEM. The first U.S. customer, a global semiconductor manufacturer, will take delivery of the new JEM-2800 with large solid angle EDS this summer. 

For more information: http://www.jeolusa.com/PRODUCTS/ElectronOptics/TransmissionElectronMicroscopesTEM/200kV/JEM2800/tabid/813/Default.aspx

Automated Oil Evaporator for Difficult Samples

JM Science is proud to announce the New AQUACOUNTER® AQL-2320 Automated Oil Evaporator Karl Fischer Titration System. This system has been designed for analyzing moisture in difficult samples like oil, grease, peanut butter, paint, resins, bonding agents etc. Using an azeotropic distillation solvent like toluene or xylene, moisture can be evaporated at a lower temperature thus saving on expensive Karl Fisher reagents and lower maintenance costs since the titration cell remains clean and free of contaminants. Heat samples up to 200ºC. and automate the addition of the azeotropic solvent easily. The sample tray can hold 20 samples and the operator can even automate the exchange of Karl Fisher reagents. Simply load the sample try and push “start” thus saving time and money.  Low operating costs and very attractive pricing make this a must-have system for any lab working with difficult sample.

For more information contact us at 1-800-495-1678 or visit us at www.jmscience.com

University of Glasgow expands its fabrication capabilities with additional Oxford Instruments systems

The James Watt Nanofabrication Centre in Glasgow, UK, has added a PlasmaPro^® System100 ICP plasma etch system to its existing installed base of Oxford Instruments etch and deposition tools. The PlasmaPro System100 ICP will be used to etch compound semiconductors materials used in applications such as optoelectronics, mm-wave & terahertz, bioengineering, biotechnology, lab-on-a-chip, energy harvesting and photovoltaics.

Mark Vosloo, Sales and Marketing Director at Oxford Instruments comments, “As a company Oxford Instruments is focussed on developing leading edge tools for research and development, and this additional system order for Oxford Instruments tools emphasises our commitment to providing the research equipment of choice for the University of Glasgow.”

“We have been working closely with Oxford Instruments for many years, utilising their etch and deposition systems successfully for our research.”, said Prof Douglas Paul, Professor of Semiconductor Devices and Director of the James Watt Nanofabrication Centre, “We placed this recent order for an additional Oxford Instruments system as we continue to be impressed by the tools’ flexibility and performance. We have used their tools for many years, and continue to use them to develop new etch and deposition processes for nanofabrication as we push technology below 5 nm feature sizes. In addition, maintaining our equipment is vital in order to maximise our usage and investment, and we are extremely satisfied with the consistent high levels of support we receive from Oxford Instruments”

Oxford Instruments aims to pursue responsible development and deeper understanding of our world through science and technology, using innovation to turn smart science into world-class products that support research and industry.

NEW Wireless Data Collector for Temperature & Humidity

The NEW user-friendly and surprisingly affordable log-EZ from TandD Corp. can be easily used to measure and record temperature and humidity in various places such as laboratories, production facilities, warehouses, office buildings, homes or any location where these parameters are important.
It is possible to manage data recorded by multiple log-EZ units that are placed in distant rooms, via one computer. The range of each log-EZ is up to 150 ft. and up to 16 loggers can be connected to a single system. By “daisy-chaining” the individual loggers, communication over a considerable distance can be achieved.
Wireless communication makes data transmission easy and simple with no need for cables or gathering the log-EZ units to collect the data.

These low cost units have a temperature range of 0 to 50°C (±1°C) and a humidity range of 15 to 90% RH (±6%RH), which are can be viewed on a large and easy to read LCD display.

The log-EZ records data and can store 1,440 readings. Current readings can be viewed in real-time on a PC, and recorded data can be automatically downloaded and archived for future reference.

For ultra-simple setup, the kit includes the RTR-322 Recorder, the RTR-320 USB Transceiver, software and mounting bracket.

For additional information on the NEW log-EZ Wireless Data Collector contact:
TandD CorporationPO Box 321
Saratoga Springs, NY 12866 USA
Phone: 518-669-9227
E-mail: inquiries@tandd.com
Web: http://www.tandd.com/

Just Published: Journal of Chromatography A

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5248

New JEOL Large Angle Energy Dispersive Spectrometer (EDS) for Ultrafast Elemental Mapping of S/TEM Samples

JEOL has developed a new generation of Energy Dispersive Spectrometer (EDS) for ultrafast, ultrasensitive collection of X-rays through analysis with its Scanning Transmission Electron Microscopes (S/TEM).  Centurio from JEOL is a novel Silicon Drift Detector (SDD) EDS that collects X-rays from samples at an unprecedented large solid angle of up to 0.98 steradians from a detection area of 100mm². The larger the solid angle of measurement, the more data the EDS collects to construct detailed analytical maps of the elements in the sample.

With the ability to efficiently collect x-rays at very high count rates, Centurio speeds elemental mapping and improves element detection sensitivity without loss of energy resolution.  Large pixel number EDS maps can be made at rates ten times faster than with previous EDS designs, with excellent signal-to-noise ratio.  Combined with the large probe currents in small probe sizes attainable with aberration-corrected STEM, fast, efficient atomic resolution EDS analysis is possible. 

The automatically retractable side entry design allows fast repositioning to avoid irradiation from back-scattered electrons.

Centurio exponentially expands the elemental mapping capability for the JEOL 200kV and higher TEMs, including the JEM-ARM200F atomic resolution TEM with optional cold Field Emission Gun, and the new JEM-2800 automated, high throughput, nano-area analysis TEM. 

http://www.jeolusa.com/PRODUCTS/ElectronOptics/TransmissionElectronMicroscopesTEM/Analytical/Centuriooption/tabid/811/Default.aspx

NEW Syringe Pump Perfect for Hand-Held or Stereotaxic Injections

Harvard Apparatus, has just released the NEW Pump 11 Elite Nanomite. This Syringe Pump is exceptionally small making it perfect for space limited or remote applications.
Features include:

• Perfect for hand-held automated delivery or stereotaxic injections

• Easy-to-use touch screen with icon interface

• Create, save and run simple to complex methods without a PC

• Effortlessly transfer methods to other pumps and/or download from a PC

• Flexibility in connectivity with a footswitch input, USB serial port, RS-485 ports for daisy chaining and a digital I/O. Optional RS-232 (RJ-11) ports

• Full range of accessories - syringe heaters, in-line heaters and coolers, nanofluidic circuits, connectors, tubing, syringes and more

• Peace of mind - 2-year warranty

The expanded capabilities of the NEW Pump 11 Elite Nanomite will help the user meet and exceed their research expectations.

This single syringe Infusion/Withdrawal programmable pump offers enhanced flow performance, high accuracy and smooth flow from 3.66 pl/min to 3.818 ml/min with 11 lbs of adjustable force.

For complete specifications on these new pumps, go to http://www.harvardapparatus.com/ or contact the Harvard Apparatus Technical Support Department at techsupport@harvardapparatus.com

Harvard Apparatus84 October Hill Road
Holliston, Massachusetts 01746 USA
Toll Free: 800-272-2775
Phone: 508-893-8999
Fax: 508-429-5732
E-mail: bioscience@harvardapparatus.com
Web: http://www.harvardapparatus.com/

Just Published: Biosensors & Bioelectronics

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5223

Selected papers from the latest issue:

Adaptation to High Current Using Low External Resistances Eliminates Power Overshoot in Microbial Fuel Cells

24 July 2011, 22:24:32

Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 23 July 2011
Yiying, Hong , Douglas F., Call , Craig M., Werner , Bruce E., Logan
One form of power overshoot commonly observed with mixed culture microbial fuel cells (MFCs) is doubling back of the power density curve at higher current densities, but the reasons for this type of overshoot have not been well explored. To investigate this, MFCs were acclimated to different external resistances, producing a range of anode potentials and current densities. Power overshoot was observed for reactors acclimated to higher (500 and 5000Ω) but not lower (5 and 50Ω) resistances. Acclimation of the high external resistance reactors for a few cycles to low external resistance (5Ω), and therefore higher current densities, eliminated power...

Color ChangingBlock Copolymer Films for Chemical Sensing of Simple Sugars

24 July 2011, 22:24:32

Publication year: 2011
Source: Biosensors and Bioelectronics, In Press, Accepted Manuscript, Available online 23 July 2011
Omar B., Ayyub , Jennifer W., Sekowski , Ta-I, Yang , XinZhang , Robert M., Briber , ...
We investigated the use of functionalized photonic block copolymer films for the detection of glucose. Polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) block copolymers were chemically functionalized with 2-(bromomethyl)phenylboronic acid and cast into films that reflect a visible color when exposed to aqueous media. The 2-(bromomethyl)phenylboronicacidfunctionality can reversibly bind to glucose. When exposed to high concentrations of glucose the polymer responded with a redshift in color. Low concentration exposure of glucose caused the polymer films to blueshift in color. The BCP films also exhibited a selective response to fructose, mannose or galactose, giving a different response depending on which sugar is present. The color...

Just Published: Trends in Analytical Chemistry

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5787

Selected papers from the latest issue:

Current instrumentation for aerosol mass spectrometry

18 July 2011, 22:26:40

Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Kari, Hartonen , Totti, Laitinen , Marja-Liisa, Riekkola
This review describes recently presented instrumental set-ups for aerosol mass spectrometry (AMS), most being suitable for in-situ analysis. AMS allows the analysis of atmospheric aerosol particles within a short time interval and without sample pretreatment, and it is less sensitive to artifact formation than conventional sampling and analytical techniques. Although a quantitative measure of total organic loading can be obtained with some AMS instruments, they currently give only limited information on specific compounds. When the ionization technique produces a large number of fragments for a compound, it becomes impossible to track the original compound. Moreover, at present, there is no...

Recent advances in clinical microdialysis

18 July 2011, 22:26:40

Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter, Matzneller , Martin, Brunner
Clinical microdialysis (MD) is a minimally invasive sampling technique that offers selective, in-vivo measurement of free, active drug or biomolecule concentrations in human tissues and organs. From a regulatory perspective, MD can thus be seen as a suitable scientific tool that meets regulatory requirements for the study of tissue distribution or bioequivalence during drug development. From a clinical perspective, the use of MD in different applications has shown the potential to rationalize drug-dosing regimens and to influence clinical decision-making, although validation and correlation of MD-derived results with clinical response are required to promote routine clinical use of the technique. From...

Solid-phase extraction and high-performance liquid chromatography mass spectrometry analysis of nitrosamines in treated drinking water and wastewater

18 July 2011, 22:26:40

Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
J.M., Boyd , S.E., Hrudey , S.D., Richardson , X.-F., Li
N-Nitrosamines, including N-dimethylnitrosamine (NDMA), were identified as chlorination byproducts in drinking water in 1989. Nitrosamines are known rodent carcinogens and probable human carcinogens, so that they have been considered disinfection byproducts (DBPs) of public health concern. Epidemiological studies show a potential association of consumption of chlorinated drinking water with an increased risk of bladder cancer. As small, relatively polar DBPs that often occur at low-ng/L concentrations in water, nitrosamines pose analytical challenges for accurate determination. Sample preparation (e.g., commonly used solid-phase extraction) plays a critical role in achieving reliable determination of nitrosamines at ng/L concentrations. Historically, gas chromatography (GC)-based techniques...

Modulators for comprehensive two-dimensional gas chromatography

18 July 2011, 22:26:40

Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Peter Quinto, Tranchida , Giorgia, Purcaro , Paola, Dugo , Luigi, Mondello
The analytical benefits of comprehensive two-dimensional gas chromatography (GC×GC) methods have been exploited and emphasized in the past two decades. The unexpectedly complex nature of many real-world samples amenable to GC analysis has been elucidated through the enhanced resolving power of GC×GC. Simple but fundamental devices, called modulators, enable continuous heart-cutting and re-injection, without which GC×GC analysis cannot be achieved. The present review focuses on the history (1991–2010), and present trends and future prospects for GC×GC modulation. We provide detailed descriptions and set out the advantages and the disadvantages of the most significant thermal and pneumatic modulators.

Climate-change impacts on water chemistry

18 July 2011, 22:26:40

Publication year: 2011
Source: TrAC Trends in Analytical Chemistry, In Press, Accepted Manuscript, Available online 18 July 2011
Philippe, Quevauviller , Yoshio, Umezawa

Fluidigm launch Customer Web Videos

Fluidigm has added a new genre - customer web videos (www.fluidigm.com/biomark-videos.html) to the wide array of topical information (publications, application notes, posters, newsletters, press releases) available from its website.

Eve Marquis, Marketing Manager of Fluidigm Europe commented "Online video creates a more personal interaction between Fluidigm and our target audience in Single Cell, Gene Expression, SNP Genotyping, Next Generation Sequencing and Copy Number Variation markets. The use of both visual effects and commentary from existing customers is a great way of effectively communicating the value of implementing Fluidigm technological solutions in your lab. In today's fast paced world, it is much more efficient for someone to click on a video link than it is for them to read a page of text. People want fast and easy information, and web video allows them to have that".

The first customer web video from Dr Paul Robson from the Genome Insitute of Singapore reports on how he and fellow scientists have generated significant single cell expression data crucial for a detailed molecular understanding of mammalian development from fertilization to embryo implantation, a process known as the preimplantation period. The knowledge gained has a direct impact on clinical applications in the areas of regenerative medicine and assisted reproduction.

A further customer web video from Professor Mylene Yao of Stanford University reports upon her group's pioneering work using Fluidigm IFC technology to undertake single embryo gene expression has allowed them to gain a better understanding of early embryo development.

Social Media Pages for Dynamic Light Scattering

Avid Nano has announced that it has launched Facebook, LinkedIn and Twitter pages to facilitate simple communication about topics involving Dynamic Light Scattering via its website - http://www.avidnano.com/.

Visitors to the social media pages can learn about the latest innovations and applications advances in dynamic light scattering technology, obtain information on industry trends and events, and share feedback with Avid Nano and the life sciences community.

Maria Cunningham of Avid Nano commented 'Our aim in establishing and maintaining the social media pages is to facilitate two-way dialog and flow of information about topics of interest to the DLS community'. She added 'We welcome comments and suggestions to help improve this new facility'.

Dynamic light scattering is a non-invasive technique that enables quick and accurate measurement of hydrodynamic radius, size distribution, estimated molecular weight and aggregate content of biomolecules and nanoparticles in solution or suspension.  Avid Nano DLS systems find particular utility in applications including crystal screening, buffer optimisation, solubility screening, aggregate detection, micelle formation, engineered nanoparticles and formulation development.

Operating from its UK headquarters - Avid Nano is building a strong reputation for its technical expertise, applications support and delivering DLS systems that reliably deliver top quality results.  For further information please contact Avid Nano via its website or telephone +44-1494-614659 / email info@avidnano.com.

Just Published: Journal of Chromatography A

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5248

Selected papers from the latest issue:

Dispersive liquid-liquid microextraction using non-chlorinated, lighter than water solvents for gas chromatography-mass spectrometry determination of fungicides in wine

24 July 2011, 20:44:11

Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 24 July 2011
T., Rodríguez-Cabo , I., Rodríguez , M., Ramil , R., Cela.
A novel and low solvent consumption method for the sensitive determination of fungicide residues in wine samples is proposed. Analytes were extracted by dispersive liquid-liquid microextraction (DLLME) and further determined by gas chromatography-mass spectrometry (GC-MS). Under optimized conditions, a binary mixture of acetone and 1-undecanol (0.5 and 0.05mL, respectively) was used to extract target compounds from diluted (1:1) wine samples. After centrifugation, the floating phase of 1-undecanol was solidified and separated from the liquid hydro-alcoholic matrix. Thereafter, it was allowed to melt at room temperature and injected in the GC-MS system. The method showed relative standard deviations (RSDs, %) below...

High performance liquid chromatopgraphy column packings with deliberately broadened particle size distribution: relation between column performance and packing structure

24 July 2011, 20:44:11

Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 24 July 2011
Anuschka, Liekens , Jeroen, Billen , Ron, Sherant , Harald, Ritchie , Joeri, Denayer , ...
The effect of the addition of 25%, 50% and 75% (weight percent, wt%) of larger particles (resp. 3 and 5μm) to a commercial batch of 1.9μm particles has been investigated as an academic exercise to study the effects of particle size distribution on the kinetic performance of packed bed columns in a magnified way. Comparing the performance of the different mixture in a kinetic plot, it could be irrefutably shown that the addition of larger particles to a commercial batch of small particles can not be expected to lead to an improved kinetic performance. Whereas the addition of 25 wt%...

Development of a multi-residue method for the determination of organic micropollutants in water, sediment and mussels using gas chromatography-tandem mass spectrometry

24 July 2011, 20:44:11

Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 24 July 2011
Juan, Sánchez-Avila , María, Fernandez-Sanjuan , Joana, Vicente , Silvia, Lacorte
This study describes the development of a multiresidue method based in gas chromatography-electron ionization-tandem mass spectrometry (GC-EI-MS/MS) for the detection of sixteen polycyclic aromatic hydrocarbons (PAHs), five phthalate esters (PEs), seven polychlorinated biphenyls (PCBs), six polybrominated diphenyl ethers (PBDEs), six alkylphenols (APs), three organochlorined pesticides and their isomers or degradation products (OCPs) and bisphenol A in seawater, river water, wastewater treatment plant (WWTP) effluents, sediments and mussels. Solid phase extraction (SPE) was used for the extraction of target analytes in aqueous samples, and ultrasound assisted extraction for solid samples. GC-EI-MS/MS acquisition conditions in selected reaction monitoring (SRM) using two transitions...

Simultaneous Determination of Flonicamid and Its Metabolites in Vegetables Using QuEChERS and Reverse-Phase Liquid Chromatography Tandem Mass Spectrometry

24 July 2011, 20:44:11

Publication year: 2011
Source: Journal of Chromatography A, In Press, Accepted Manuscript, Available online 24 July 2011
Yong, Xu , Lin-Fei, Shou , Yin-Liang, Wu
This paper presents a rapid analytical method for the simultaneous determination of flonicamid and its metabolites N-(4-trifluoromethylnicotinoyl) glycine (TFNG), 4-trifluoromethylnicotinic acid (TFNA), and 4-trifluoromethylnicotinamide (TFNA-AM) in vegetables using QuEChERS by liquid chromatography tandem mass spectrometry (LC-MS/MS). Samples were extracted with acetonitrile. The extract was purified through QuEChERS method with primary secondary amine (PSA) and graphite carbon black (GCB). Then the extract was diluted with 0.1% formic acid in water, and analyzed by LC-MS/MS on a Waters Acquity BEH C18 column with methanol/0.1% formic acid in water as mobile phase with gradient elution. The linearity of the analytical response across the...

Just Published: Journal of Chromatography B

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/7220

Selected papers from the latest issue:

Development and validation of an EI-GC/MS method for the determination of sertraline and its major metabolite desmethyl-sertraline in blood

21 July 2011, 21:49:43

Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 20 July 2011
Alaa, Khraiwesh , Ioannis, Papoutsis , Panagiota, Nikolaou , Constantinos, Pistos , Chara, Spiliopoulou , ...
Α sensitive and specific GC/MS method for the determination of sertraline and its main metabolite desmethyl-sertraline in whole blood has been developed, optimized and validated. Sample preparation included solid-phase extraction of both analytes and their derivatization with heptafluorobutyric anhydride (HFBA). Protriptyline was used as internal standard for the determination of both analytes. Limits of detection and quantification for both sertraline and desmethyl-sertraline were 0.30 and 1.00μg/L, respectively. The calibration curves were linear within the dynamic range of each analyte (1.00-500.0μg/L) with a correlation coefficient (R2) exceeding 0.991. Extraction efficiency ranged from 90.1(±5.8) to 95.4(±3.0) % for sertraline, and from 84.9(±8.2)...

The Effects of Hitchhiker Antigens Co-Eluting with Affinity-Purified Research Antibodies

21 July 2011, 21:49:43

Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 20 July 2011
Lilly, Mechetner , Radhika, Sood , Van, Nguyen , Pete, Gagnon , Missag H., Parseghian
The popularity of Protein G for the purification of antibodies has given rise to an entire industry that supplies scientists with research grade immunoreagents; however, many times the supplied product is contaminated with antigens bound to the antibody's complementarity-determining regions (CDRs). These “hitchhikers” are a category of host cell proteins that are elusive to detect due to their interaction with the antibody in the final product and yet their impact on an experiment or an entire field of study can be far reaching. In an earlier work, the role of hitchhikers on a human anti-histone antibody destined for clinical usage...

Self-assembly molecularly imprinted polymers of 17β-Estradiol on the surface of magnetic nanoparticles for selective separation and detection of estrogenic hormones in feeds

21 July 2011, 21:49:43

Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 20 July 2011
Shu, Wang , Yun, Li , Meijuan, Ding , Xiaoli, Wu , Jinhui, Xu , ...
This paper reports a surface molecular self-assembly strategy for molecular imprinting on magnetic nanoparticles for selective separation and detection of estrogens in feeds. First, γ-methacryloxypropyltrimethoxysilane (MEMO) was successfully assembled at the surface magnetic nanoparticles through simple free radical polymerization, and subsequently, the copolymerization was further assembled between methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) in the presence of templates 17β-Estradiol (E2). The synthesized magnetic molecularly imprinted polymers for E2 (E2-MMIPs) showed quick separation, large adsorption capacity, high selectivity and fast binding kinetics for E2. Meanwhile, a dispersive solid-phase extraction (DSPE) based on E2-MMIPs has been established for efficient separation...

COMPARATIVE STUDY OF LC-MS/MS AND UPLC-MS/MS FOR MULTI-RESIDUE ANALYSIS OF QUINOLONES, PENICILLINS AND CEPHALOSPORINS IN COW MILK, AND VALIDATION ACCORDING TO THE REGULATION 2002/657/EC

21 July 2011, 21:49:43

Publication year: 2011
Source: Journal of Chromatography B, In Press, Accepted Manuscript, Available online 20 July 2011
A., Junza , R., Amatya , D., Barrón , J., Barbosa
The aim of this study was to develop and validate an analytical method to simultaneously determine European Union-regulated β-lactams (penicillins and cephalosporins) and quinolones in cow milk. The procedure involves a new solid phase extraction (SPE) to clean-up and pre-concentrate the three series of antibiotics before analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). LC-MS/MS and UPLC-MS/MS techniques were also compared. The method was validated according to the Directive 2002/657/EC and subsequently applied to 56 samples of raw cow milk supplied by the Laboratori Interprofessional Lleter de Catalunya (ALLIC) (Laboratori Interprofessional Lleter de Catalunya,...

Accurate & Precise Micro Determination of Fluorine

Operating in an ISO 17025 and GMP accredited environment, Warwick Analytical Service has developed proprietary analytical procedures to enable accurate and precise data to be produced for all types of samples including organic samples with trace levels of Fluorine. 

From extensive method validation typical results are within the ±0.3% absolute limits considered acceptable for micro chemical analysis. The WAS method can detect 0.01ppm fluoride which is equivalent to 0.02% in a 10mg sample.  WAS has developed special procedures to remove interferences from samples containing boron, calcium or sulfur.

Offered by Warwick Analytical Service (WAS) as an analytical service, analysis of Fluorine is carried out by combustion of an accurately weighed sample in a silica oxygen flask over an accurately measured volume of water and TISAB buffer solution.  A fluoride ion selective electrode is used to directly measure the potential of a range of fluoride solutions.  The potential of the combusted samples are measured under the same conditions.  The concentrations of the sample solutions are calculated from the derived calibration curve. Sets of work typically include certified reference materials or organic analytical standards.  Results from these standards and the electrode response are monitored to detect trends in the method.

The accurate micro determination of fluorine in organic compounds is of significant interest to a wide array of industries including food and beverages, environmental monitoring, medical, pharmaceutical and polymers.

Warwick Analytical Service (WAS) is a company dedicated to providing analytical excellence at a realistic cost. Through experienced staff, the latest analytical instrumentation and working closely with clients - WAS has established a strong reputation for informed personal service and delivering top quality data on time. Operating from a dedicated facility approved to BSI ISO 9001 and with a wide range of analytical techniques accredited to UKAS ISO17025 - WAS has become the trusted analytical services provider for a growing number of UK and international businesses. From its modern, well-equipped facility in Coventry, UK - Warwick Analytical Services offers a wide range of analytical techniques including elemental analysis (ICP, CHNS, Halogen analysis), Optical Rotation, NMR, MS, FT-IR, Thermal Analysis and Particle sizing on a contract basis.

For full details of micro determination of fluorine in organic compounds please contact Warwick Analytical Service on tel. +44-2476-323223 or email info@warwickanalytical.co.uk

Just Published: Sensors & Actuators B: Chemical

A new issue of this journal has just been published. To see abstracts of the papers it contains (with links through to the full papers) click here:

http://rss.sciencedirect.com/publication/science/5283

Selected papers from the latest issue:

Water diffusion in polymer nano-films measured with microcantilevers

20 July 2011, 23:14:24

Publication year: 2011
Source: Sensors and Actuators B: Chemical, In Press, Accepted Manuscript, Available online 20 July 2011
Chuanjun, Liu , Marcus C., Lopes , Sascha A., Pihan , Daniela, Fell , Mordechai, Sokuler , ...
We present a method to measure the absorption of water molecules from the liquid and the vapour phase into polymer nanofilms and the diffusion inside these films. Film thickness can be down to 45nm. To demonstrate the possibilities of this method we use polymer films that are deposited on the upper side of a silicon cantilever by plasma polymerization of norbornene. When a microdrop of water is deposited onto the initially straight cantilever, the drop causes the cantilever to bend while it evaporates. Evaporation of such small water drops usually takes less than a second. An upwards bending is due...

Plasma Enhanced-CVD of undoped and fluorine-doped Co3O4 nanosystems for novel gas sensors

20 July 2011, 23:14:24

Publication year: 2011
Source: Sensors and Actuators B: Chemical, In Press, Accepted Manuscript, Available online 20 July 2011
Davide, Barreca , Daniela, Bekermann , Elisabetta, Comini , Anjana, Devi , Roland A., Fischer , ...
Co3O4-based nanosystems were prepared on polycrystalline Al2O3 by plasma enhanced-chemical vapor deposition (PE-CVD), at temperatures ranging between 200 and 400°C. The use of two different precursors, Co(dpm)2 (dpm=2,2,6,6-tetramethyl-3,5-heptanedionate) and Co(hfa)2•TMEDA (hfa=1,1,1,5,5,5-hexafluoro-2,4-pentanedionate; TMEDA=N,N,N’,N’-tetramethylethylenediamine) enabled the synthesis of undoped and fluorine-doped Co3O4 specimens, respectively. A thorough characterization of their properties was performed by glancing incidence X-ray diffraction (GIXRD), atomic force microscopy (AFM), field emission-scanning electron microscopy (FE-SEM), secondary ion mass spectrometry (SIMS) and X-ray photoelectron spectroscopy (XPS). For the first time, the gas sensing properties of such PE-CVD nanosystems were investigated in the detection of ethanol and acetone. The results show an...

Preparation of ZnO Nanorods by Microemulsion Synthesis and Their Application as a CO Gas Sensor

20 July 2011, 23:14:24

Publication year: 2011
Source: Sensors and Actuators B: Chemical, In Press, Accepted Manuscript, Available online 20 July 2011
Sang Kyoo, Lim , Sung-Ho, Hwang , Soonhyun, Kim , Hyunwoong, Park
Zinc oxide nanorods with different surface area were synthesized by surfactant assisted microemulsion method. The alkyl chain length of surfactant would affect aspect ratio of ZnO nanorods. ZnO nanorods synthesized by ethyl benzene acid sodium salt (EBS), which is surfactant with short alkyl chain length, show higher aspect ratio than ones by dodecyl benzene sulfonic acid sodium salt (DBS). These nanorods had diameters in the range of 80 ∼ 300nm and length of up to several microns. The Brunauer-Emmett-Teller (BET) surface area of the ZnO nanorods was strongly affected by the morphology of the nanorods. The BET surface area of...

CE method development and validation course

CE method development and validation course on 22 and 23 November 2011 in Amsterdam. Please forward this invitation to anyone it may concern.

This course aims for analytical scientists and technicians who want a better understanding of the capillary electrophoresis techniques and practical approach for method development and validation. We’ll work from the understanding of the separation mechanisms in CE in order to rationally develop robust and reliable test methods. Simultaneously, a better understanding of the need and requirements for validation will help select appropriate specifications and tests for the validation protocol.

Deadline for early registration is 15 Sep 2011. Link to Registration form. Limited space available.

Kantisto BV is a pharmaceutical analytical chemistry training and consultancy with:

•       Focus on implementation and good working practices

•       On-the-job training and coaching

•       Courses and workshops

•       A pragmatic, scientific and personal approach

•       Specialties: Separation techniques, CE, CE-MS, Dissolution, Chiral separations, Quality by Design QbD, Application development, validation and transfer, Troubleshooting, Support on CMC and Regulatory documentation, GLP, GMP.

More information on www.kantisto.nl.