New Fluorescence-Based Detection of pH, CO2 and O2

This NEW Fluorescence-based optical Biosensor from Harvard Apparatus represents a breakthrough technology in the measurement of typical blood gas parameters in tissue engineering, organ perfusion and general physiology applications.

Features include:

• More accurate measurements than traditional methods
• Sensitive sensors are also rugged for long life
• No electrolytes required
• Completely sterilizable sensors
• USP Class VI-certified sensors are shipped pre-calibrated
• Minimal chemical degradation means usage life and infrequent recalibration

In contrast to traditional ion-sensitive chemosensors, these optical biosensors use a controlled optical source that emits light signals at specified frequencies which excite an ion-specific sensor spot in contact with the test medium.

Changes in the parameter of interest are reported as a proportional change in some characteristic (intensity, phase shift, etc.) of the fluorescence. Because they are inherently self-referencing, this detection technology eliminates the potential for measurement error arising from changes in sample properties (i.e. flow rate, viscosity, etc.) over the duration of an experiment. This ensures stable, drift-free calibration and hence reliable measurements throughout the lifespan of a sensing element.

Unlike polarographic oxygen electrodes, this technology is non ion-consumptive. These easy-to-use biosensors are free of the maintenance complications inherent in traditional chemosensing: requiring only cleaning and dry storage, there is no need for electrolyte, membrane changes, or pre-polarization of the electrode amplifier.

For more information contact:

Stephanie Pazniokas, M.S. spazniokas@harvardapparatus.com

Combining Cell Biology and Molecular Genetics for Single-Cell Research

Fluidigm Corporation has announced a collaboration with BD Biosciences, a segment of BD (Becton, Dickinson and Company), to co-host a public seminar series on the isolation and analysis of single cells. Entitled 'A Powerful Technique for Single-Cell Analysis', the public seminar series will showcase cell isolation using the BD FACSAria™ III Cell Sorter and analysis using the Fluidigm BioMark™ HD System.

The combination of the cell surface phenotype obtained from cell sorting and the gene expression profiles of individual cells isolated from a heterogeneous population of cells provides a deeper view into cellular systems.

"We believe this emerging field of single-cell genomics research will help elucidate the underlying biomolecular processes across many diverse biomedical research areas," said Gajus Worthington, Fluidigm president and chief executive officer. "Numerous publications in the last two years have shown that the BioMark System enables important observations of single-cell behavior in a number of biologically relevant fields, including stem cell research, cancer research, immunology and developmental biology," Worthington added.

Utilizing cellular and molecular biology to profile single-cell populations alleviates the complexity caused by cell heterogeneity.  BD cell sorting systems (such as the BD FACSAria III Cell Sorter) provide scientists the flexibility to isolate single cells of interest from thousands of cells in a population using up to 18 surface markers. Assessment of cellular heterogeneity and cellular biomolecular processes is obtained by assaying for differential expression levels using the BioMark HD System.

"Since the introduction of the powerful BD FACSAria III Cell Sorter, its immediate improvement on sensitivity and ease-of-use opened the complex world of cell sorting to a broader audience of researchers, enabling them to perform a wider range of applications," said James Glasscock,  President, BD Biosciences - Cell Analysis. "We believe that joining our expertise in cell sorting with Fluidigm's ability to provide real-time polymerase chain reaction gene expression profiles of hundreds of genes from multiple minute samples will greatly simplify and advance single-cell research."  

The seminar series will discuss the experimental workflows of both companies' technologies -- BD FACSAria III Cell Sorter and the Fluidigm BioMark HD System -- that reveal cell population heterogeneity. These public seminars are currently being held throughout North America.

New High Throughput Submarine Gel Electrophoresis Unit

Hoefer, Inc. has introduced their NEW SUBHT High Throughput Submarine Gel Electrophoresis Unit. This new unit is:

• Fast- Run an entire 96-well plate of samples (plus up to 24 control or marker lanes) in 30 minutes.
• Error-Free- Multi-channel pipette compatible well spacing and labeled gel running tray insure positive ID of loaded samples
• Customizable- A large selection of different combs and accessories allows you to optimize this unit for your particular application.

There have been many advances over the years to push the throughput of PCR based assays. However, these throughput gains are often lost when traditional electrophoresis is used.

The NEW SUBHT High Throughput Submarine Gel Electrophoresis Unit provides rapid, error-free nucleic acid analysis. Quickly load the contents of an entire 96-well plate in 8 easy steps with a multi-channel pipette.

The UV transparent gel running tray contains fluorescent labels that correspond with every well on the 96-well sample plate. Error- free gel image capture and analysis is simply done by placing this running tray directly on a UV transilluminator.

For complete details and technical specifications, please visit http://www.hoeferinc.com/ or e-mail the Hoefer Technical Support Team at support@HoeferInc.com.

Analytical Technology Secures New Framework Agreement

Specialist electrochemical sensor manufacturer Analytical Technology Inc. today announces that it has been awarded the framework agreement to supply and install triple validated chlorine monitoring systems to Thames Water. The new chlorine monitoring systems will replace Thames’ existing instrumentation, improving process control and enabling considerable operational and maintenance savings in line with current company strategy. The new framework agreement reinforces Analytical Technology’s position as a leading provider of water monitoring instrumentation to many of the UK’s largest utility companies.

Following a lengthy and detailed decision-making process, Analytical Technology was awarded the framework agreement by Thames Water in February 2011, beating off competition from six of the world’s leading providers. The company scored significantly higher than its competitors in all three characteristics on which the award was based, achieving scores 20% higher than all other companies in areas including commercial, technical and term and conditions of trade (T&C). Thames Water currently has the UK’s largest installed base of chlorine monitors and is investing in the new technology during AMP 5, the asset management plan period between 2010 and 2015. Due to the large size of the order, the new framework agreement was jointly awarded to both Analytical Technology and Siemens.

Analytical Technology launched its UK and Europe business in 1998 and the company has enjoyed growing success, now providing compliant instrumentation to most UK water providers and leading the way in developing reliable and cost-effective monitoring systems. Developing and producing the highest quality instruments available, Analytical Technology recently added the Profibus DP standard to its monitoring systems, enabling water and wastewater treatment plants to optimise maintenance and achieve a high level of confidence in chlorine measurement. The triple validated chlorine monitoring systems selected by Thames Water will enable them to improve process control and make great savings over the whole life of the asset. 

Garry Tabor, Sales Manager Europe at Analytical Technology, comments: “Our goal was clear; Analytical Technology set out to be the UK's number one supplier of chlorine monitoring systems and this new framework agreement is a great reward for our dedicated team. We have been working with all the UK's major water companies for some time and have been able to pass on operational costs which amount to hundreds of thousands of pounds. This is backed up by our dedication to providing top quality service to our customers, which includes personalised training programmes and maintenance services. This award confirms our claims that Analytical Technology’s chlorine monitors are the best on the market, with no rivals either technically or commercially.” 

In addition to Thames Water, Analytical Technology has the frameworks to supply chlorine monitors to Scottish Water, United Utilities, South West Water and Yorkshire Water.

For more information on Analytical Technology’s triple validated chlorine monitoring systems, please call +44(0)1457 873 318, e-mail sales@atiuk.com or visit http://www.analyticaltechnology.com/

Thermo Fisher Scientific Expands its Range of Ultra Pure Inorganics

Thermo Fisher Scientific Inc., the world leader in serving science, today announced that it has significantly expanded its range of Acros Organics Ultra Pure Inorganics products to meet increasing demand in high-technology industries and other chemistry applications.

This portfolio, which is now 50 percent larger, features new high-purity inorganic compounds with ultra-low metal contaminants, which are critical in specific high-technology applications such as petroleum refining, micro-electronics, energy and space technology, communications and other industries. This includes their use in the catalysis of reactions and crystal growth as well as the manufacture of photovoltaic materials, optical fibers and lasers. These extremely pure inorganics have trace-metal content of less than 100 ppm to as low as 1 ppm.

The Acros Organics Ultra Pure Inorganics line is featured in a recently released brochure that provides full product description, extended details of their potential uses, chemical purity information and product codes for easy ordering. The new brochure can be downloaded at www.acros.com.

For further information please visit http://www.acros.com/

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit http://www.thermofisher.com/.

NEW Ergonomic Elbow Pad Eases Pipetting Discomfort

Pipetting is sometimes heavy work, hands and shoulders get fatigued easily in long pipetting series.

Users can improve their working posture with the NEW Biohit Elbow Pad. The Elbow Pad is ergonomically designed to provide the user with a more relaxed pipetting position.

The visco elastic material of the pad relieves contact stress, pain and discomfort during pipetting.

The Elbow Pad is ideal for:

• Long pipetting series
• Work requiring high concentration, e.g. micro plate work or micro volume pipetting
• Pipetting work in a laminar hood

Features and benefits include:

• Improves pipetting ergonomy
• Fits all sizes of elbows
• The compact size takes up little desk space
• Made of visco elastic material which conforms according to body shape

For complete information on the Biohit Line in the North America contact:
Biohit Inc.,3535 Route 66, Building # 4,
Neptune NJ 07753, USA.
Telephone: 800-922-0784
or 732-922-4900.
FAX: 732-922-0557.
E-mail: pipet@biohit.comVisit the Biohit website at: http://www.us.biohit.com/

New Production Centrifuge for The Bioprocessing Industry

Celeros Inc. has launched their NEW Model APD-250 Centrifuge employing a tubular bowl with a working volume of 40 liters.

This NEW unit is 8 times larger than their highest capacity systems currently in use enabling the system to process bioreactor harvests of up to 10,000 liters in a single shift.

The APD-250 is a large scale production centrifuge that is capable of generating up to 20,000 x G of separating force producing the driest paste and clearest centrate of any industrial centrifuge available for the biotech industry.

The Celeros APD-250 Centrifuge utilizes a patented Automatic Piston Discharge (APD) system to completely transfer separated solids from the bowl without operator intervention or excessive loss of centrate.

“The Celeros APD series centrifuges generate the highest production yields for a centrifugation step in the industry. Until now, their use has been limited by capacity to development labs or small scale manufacturing applications.” Said Wayne Nettnay, V.P. of Sales & Marketing.

“This high capacity machine extends the innovative Celeros technology into large scale manufacturing environments. This breakthrough separation system sets new standards for yield and purity and will provide tremendous economic benefits. ”

For additional information visit http://www.celerosinc.com/

Contact:

Celeros Inc.Worldwide Sales
2 Annette Road, Suite 2
Foxboro, MA 02035 USA

Greg Cybulski
Phone: 508-698-3080 x109
e-mail: Greg.Cybulski@celerosinc.com

Zero Crosstalk Luminescence Assay Plate

Constructed in ultra-pure grade polystyrene, the opaque white Krystal 2000 plate from Porvair Sciences Ltd. maximises reflectivity enabling even weakly emitting luminescence assays to be routinely undertaken.

Designed for luminescence applications that require the highest levels of photometric accuracy and repeatability the Krystal 2000 white microplate (well volume - 350 microlitres) incorporates a unique clear cup design that eliminates the performance-limiting well-to-well light crosstalk inherent in most other clear bottomed microplate designs.
 
In addition to optimised luminescence measurements the unique design of the Krystal 2000 white plate offers improved cell binding efficiency and allows the convenience of direct measurements on bottom reading spectrophotometers and inverted microscopes.

Maintaining industry standard 96-well microplate dimensions the Krystal 2000 white microplate is fully compatible with all commercially available luminometers, multimode readers, robotic sample processors and automated liquid handling systems.

For further information on the Krystal 2000 white microplate please contact Porvair Sciences Ltd. on telephone +44-1932-240255 or email int.sales@porvair-sciences.com.

Established in 1992, Porvair Sciences Ltd. expertise in microplate technology and manufacturing covers scientific fields including Life Sciences, Drug Discovery, Combinatorial Chemistry, Solid Phase Extraction, Protein Purification, High Throughput Screening, Proteomics and Genomics.  Porvair Sciences Ltd. is a wholly owned subsidiary of Porvair plc.

Wyatt Technology’s Calypso GC-MALS System Provides Fast and Accurate Measurements of Biomolecular Interactions

(Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that its Calypso Composition-Gradient Multi-Angle Light Scattering (CG-MALS) system achieves accurate measurements of biomolecular interactions. The Calypso offers the unique capability of determining both the affinity and binding stoichiometry for macromolecules in solution with no need for immobilization or tagging, which may influence the interaction. This is demonstrated in a new application note, titled “Measuring Antibody-Antigen Interactions with the Calypso”, which is available to download free-of-charge via http://www.wyatt.com/files/literature/Calypso-Measuring_Antibody-Antigen_Interactions.pdf
Antibody-antigen binding, hormone-receptor interactions and many other common biomolecular interactions occur at stoichiometries other than 1:1. Conventional separation techniques, such as size exclusion chromatography MALS (SEC MALS) and field flow fractionation MALS (FFF MALS) have been extensively used to study interactions, however they are associated with certain important limitations. As the molecules become separated in the course of dilution and fractionation, they no longer interact. Additionally, upon reaching the detectors, the molecules are often not in equilibrium, neither are they in a well defined kinetic state.
The new application note illustrates how Calypso complements traditional MALS separation techniques, keeping the molecules in close proximity to probe their interactions. The analyzer was used in conjunction with an online UV/Vis concentration detector and Wyatt’s DAWN HELEOS MALS instrument to provide rapid and precise measurements of the interaction between an anti-thrombin antibody (Ab) and human thrombin α (Thr). The equilibrium dissociation constant determined by the system agreed well with the manufacturer’s data as measured by ELISA. In addition, both thrombin and the antibody exhibited no propensity for self-association, a finding that could not be evaluated by conventional ELISA.
Calypso employs a series of unfractionated samples of different composition or concentration in order to characterize macromolecular interactions, including reversible self- and hetero-association of proteins, reaction rates and affinities of irreversible aggregation, and virial coefficients. No special modifications, such as sample tagging or immobilization procedures, are required. Instead, samples are unlabeled and entirely in solution. Furthermore, Calypso’s automation capabilities enhance productivity by improving repeatability and reliability, while minimizing time and effort.
For more information on Wyatt Technology’s instruments or to obtain a copy of the new application note, please visit http://www.wyatt.com/ or email info@wyatt.com

Ratio:Matic® Duplex Pumps for Precision Fluid Control for OEM Instrumentation

STH and STQ Ratio:Matic® Duplex pumps from Fluid Metering, Inc. are ideal for precision mixing, diluting, and proportional metering for OEM medical, analytical, and industrial instrumentation.

Ratio:Matic® pumps consist of two FMI valveless pump heads direct coupled to a single variable speed drive, standardly a 23 frame stepper motor although other drive types can be used.

The displacement of each pump head is independently adjustable, and a variety of pump head sizes can be used in combinations to achieve dispensing ratios from 1:1 up to 500:1.

Typically, each pump head is calibrated at the factory, locked in place, and will not require recalibration in the field, even after millions of cycles. Models are also available that can be adjusted in the field for applications that require frequent changes in mixing ratios or dispense volumes.

Fluid Metering’s Duplex Ratio:Matic® OEM Pumps feature FMI’s CeramPump® valveless piston pump technology. This unique pump design utilizes one moving part, a rotating and reciprocating ceramic piston to accomplish both pumping and valving functions without valves. The piston and mated liner are made of dimensionally stable, sapphire-hard ceramics which ensure long term, drift-free accuracy of 1% or better for millions of maintenance-free cycles.

For over 50 years Fluid Metering pumps have been used in operations for OEM, laboratory, chemical, pharmaceutical, mining, fuel cell & alternative energy, water treatment, filtration, environmental monitoring, food processing and much more.

For additional information, Call toll free 1-800-223-3388 or 1-516-922-6050, FAX 1-516-624-8261, email: pumps@fmipump.com or visit our website at http://www.fmipump.com/ which now features “Live Help”, an online direct connection to FMI’s application experts.

Gas Standards Generator Gives Variable Concentration at Constant Flow

KIN-TEK’s new FlexStream™ (constant flow) CF configuration combines the FlexStream™ Automated Permeation Tube System and Secondary Dilution Module to automatically create adjustable concentration gas mixtures with constant output flow using permeation tube sources.  Typically, when gas mixtures are made from permeation tubes the mixture concentration is adjusted by varying the dilution flow, so the output flow may vary over a 20:1 ratio.  This technique is effective so long as the minimum flow exceeds the application requirement, but it can be problematic when the end use requires a constant and relatively high flow rate of mixture.

With the CF configuration the primary mixture concentration can be varied over a 20:1 range in the permeation module by adjusting dilution flow as in common practice.  Then in the secondary dilution module an adjustable aliquot of the primary mixture is added to a fixed output flow to create the final mixture.  This method allows concentration adjustment over a 200:1 range without changing the output flow.

FlexStream™ software automatically adjusts dilution and aliquot flows to achieve the desired concentration in the final mixture making operation simple, convenient, and allowing remote or automated control.

For more information, please write or call:  KIN-TEK Laboratories, Inc., 504 Laurel, La Marque, TX  77568, Phone:  (409) 938-3627, Fax: (409) 938-3710, www.kin-tek.com,

email:  sales@kin-tek.com

NEW Aerosol Exposure Unit for Mice & Rats

Harvard Apparatus-Hugo Sachs Electronik has introduced its NEW Aerosol Exposure Unit (AEU) for mice and rats.

This system is ideally suited for exposing groups of mice or rats to aerosolized powders or liquids. This is Harvard Apparatus-Hugo Sachs Electronik's first system dedicated to inhalation studies in awake animal models.

The AEU is a compact system that works with up to four mice or four rats at a time. The advantage of this system is that the animals remain awake, and metabolic functions are not affected by anesthesia. Researchers also have the option of using this system with dry powders or soluble aerosols.

With the addition of data analysis software, HSE PULMODYN, the researcher can also measure respiratory parameters, such as:

• Tidal Volume
• Maximum Inspiratory and Expiratory Flow
• Respiration Rate
• Duration of Inspiration and Expiration
• Apnea Time
• Time of Brake and Time of Pause
• Airflow at 0.5TV

The AEU system is ideally suited for toxicology studies where a precise understanding of dosage is required (i.e. LD 50 or LD 100's). This system also allows for high throughput drug studies when working with aerosolized substances. The controlled delivery system is also ideally suited for reducing unknowns when working on bioavailability studies.

The AEU is a modular system and Harvard Apparatus is available to configure it for the researchers specific needs. Please contact your local sales representative or technical support member with any questions.

For more information about the Harvard Apparatus-Hugo Sachs Electronik Aerosol Exposure Unit please contact your local representative or our technical support department.

Harvard Apparatus84 October Hill Road
Holliston, Massachusetts 01746 USA
Toll Free: 800-272-2775
Phone: 508-893-8999
Fax: 508-429-5732
E-mail: bioscience@harvardapparatus.com
Web: http://www.harvardapparatus.com/

Synthetic Modified mRNA for Reprogramming of Human Cells

AMSBIO has announced the availability of highly modified synthetic 5-prime capped mRNA products for reprogramming of human cells. These new ready-to-use products provide a simple, safe non-integrating methodology for reprogramming cell fate based on the administration of synthetic modified mRNA that greatly increases efficiency whilst reducing the innate antiviral response of viral protocols.

Clinical applications of induced pluripotent stem cells (iPSCs) have traditionally been limited [1] by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPSCs toward clinically applicable cell types are not possible by viral methods.

Today AMSBIO can provide ready-to-use highly modified mRNAs including Kfl4, c-Myc, Oct4, Sox2, LIN28 mRNA, and eGFP control, in customised formats for your research. These proven synthetic adaptations of 5-prime, 3-prime and internal mRNA structures enable reprogramming of multiple human cell types to pluripotency with conversion efficiencies that greatly surpass established methods. Furthermore this same technology can be used to efficiently direct the differentiation of mRNA-induced pluripotent stem cells into terminally differentiated cells and can be employed as an alternative to DNA-based gene therapy [2].

This technology represents a safe, non-mutagenic and efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, tissue-engineering and regenerative medicine.

Drawing upon over 20 years experience - AMSBIO is able to offers a complete cell reprogramming service, from initial consultancy, synthesis of modified DNA, plasmid cloning, full DNA sequencing documentation, PCR amplification of inserts and characterization with subsequent RNA synthesis by in vitro transcription.

For further information please visit http://www.amsbio.com/synthetic-mRNA-directed-stem-cell-differentiation.aspx or contact AMSBIO on +44-1235-828200 / +1-949-768-8365 or email info@amsbio.com

NEW PRODUCT RELEASE - New Mobile Ductless Fume Hoods

Air Science USA has introduced its NEW Mobile Ductless Fume Hood.

The Mobile EDU is excellent for Classroom Demonstrations and Industrial Training. It is totally self-contained and provides all around visibility.

The EDU is easily moved from laboratory to laboratory. The Ductless Design allows easy installation and the base is mounted on large heavy duty wheels for ease of transport. The height is 77.5" which allows it to easily pass through a standard door.

The Multi-Layered EDU Filter has been independently tested to have 99.9% filtration efficiency for chemicals normally found in a typical chemistry curriculum.

These units exceed OSHA, ANSI, BSI and AFNOR Safety Standards.

For additional information on the NEW EDU Mobile Fume Hood, call, visit the website, or email Air Science.

Air Science USAPO Box 62296
Fort Myers, Florida 33906 USA

Toll Free: 800-306-0656
Phone: 239-489-0024
Fax: 800-306-0677

E-mail: info@airscience.com
Web: http://www.airscience.com/

SFT - HPR Series - High Pressure Chemical Reactors

Supercritical Fluid Technologies introduces a new series of stirred reactors for high pressure chemistry. The HPR Series Reactors have been designed for researchers who are interested in performing pressurized chemical reactions in their laboratories. Whether it is high pressure chemical synthesis or process development, the HPR Series is an excellent unit for those applications.

The reactors range in size from 50 ml to 4 liters and may be operated up to 10,000 psi and 350°C. The reactors have a magnetically coupled impeller for optimal mixing. All high pressure components are ASME rated and protected by a rupture disc for safe operation. These laboratory bench top models are ideal for applications where repetitive use makes convenience a necessity, such as catalytic studies, polymerization, hydrogenation, oxidation, isomerization, and dehydrogenation. All sizes are supplied as ready-to-use instruments requiring only utility connections prior to operation. The reactors are compact instruments that fit easily into a fume hood. Their modular design makes it simple and cost-effective to alter the unit’s basic configuration to adapt to new or evolving application needs.

All functions for the HPR Series Reactor are controlled by choices of three integrated RxTrol™ processors. The RxTrol Sr. offer advanced features utilizing a microcontroller to perform all PID, ramp/soak, process trending, mixing and interlock functions.  The RxTrol Jr. consists of (2) temperature sensors (wall/interior mounting), and fuzzy logic PID temperature controls and mixing controls in a table top assembly.  The RxTrol B consists of (2) temperature sensors (wall/interior mounting) and an open loop mixer speed control via 0-100% power output knob. 

Additional options include vessel windows (<150 degrees Celsius operation only), additional ports, cooling coils, sample loops, stand alone pressure transducers, supercritical fluids pumps and reagent addition modules.

For more information, please call us at 302-738-3420 or visit us on-line at www.supercriticalfluids.com.

Oxford Instruments Plasma Technology receives Queen’s Award

Lord Lieutenant of Somerset, Lady Elizabeth Gass visited North Somerset based company Oxford Instruments Plasma Technology this week to present its Queen’s Award for Enterprise. Top of Form

Bottom of Form

The manufacturer of high performance capital equipment for the semiconductor industry received the award for International Trade, for more than doubling overseas earnings over six years of sustained growth, and exporting over 90% of production. This outstanding performance was based on the Company’s comprehensive product range addressing a wide spread of markets combined with an aggressive strategy of developing new markets, primarily in Asia. This is the 3^rd time the company has been honoured in the Queen’s Awards.

Following a short presentation, the Lord Lieutenant toured Oxford Instruments’ manufacturing plant, research laboratories and offices in Yatton, North Somerset, and was accompanied by Mr John Cullum, High Sherriff of Somerset, and Mr Graham Turner, Chief Executive of North Somerset Council.

“It was an honour to welcome the Lord Lieutenant and other dignitaries to our facility again”, said Andy Matthews, Managing Director of Oxford Instruments Plasma Technology, “We were able to demonstrate our technology, and show the extensive improvements and growth in both facilities and workforce that have taken place recently. This award for International Trade recognises the hard work and commitment of the entire team at Oxford Instruments, and I was delighted to receive it on their behalf.

This outstanding performance was based on our comprehensive product range addressing a wide spread of markets combined with an aggressive strategy of developing new markets, primarily in Asia.”

Versatile Tube Code Reader

Micronic Europe BV, specialists in traceable sample storage solutions, have announced the introduction of the Tracxer RS210 coded tube reader.

The Tracxer provides a complete tube code reading solution for your lab whether you use 2D Data Matrix, TraXis or competitive brand coded tubes to store your samples. The reader is fully compatible with all SBS standard storage racks, which enables the reading of 24-, 48-, 96- and even 384-well formats.  Due to its compact A5 size - the Micronic Tracxer is a perfect choice for use in robotic liquid handling and storage systems. It is simple and high performance scanning at its best.

Built to deliver long-term reliability and industry leading precision - Micronic have developed new intuitive software for the Tracxer that is easy-to-use, gives reliable readings of 2D codes and provides data that is readily integrated into any laboratory sample database. With just a couple of mouse clicks of the Tracxer software you will be able to scan 96 coded tubes in less than 5 seconds. A text file is automatically generated containing a list with 96 tube codes which can be interfaced with several types of database and opened within Excel spreadsheets.

The software also includes a rack decoding feature that is able to distinguish between 2D codes that are not recognised and empty storage positions. This capability can be crucial for determining whether any samples are missing which is a vital pre-requisite for a reliable sample logistic system. The software also features 1D bar code integration.

Dedicated to the design and production of innovative sample storage tubes, accessories and instruments over the last 25 years, Micronic is uniquely able to offer laboratories the expert advice to help them safeguard one of its most valuable assets - its samples.

For further detailed information please contact Micronic Europe BV now on +31-320-277070 / sales@micronic.com.

AMSBIO Launches Technical Article Library

AMSBIO, a leading provider of innovative products and custom services for life science research, has announced a new web page (http://www.amsbio.com/amsbio_whitepapers.aspx) that brings together technical articles written by the company and its customers.

Covering research areas including stem cell biology, apoptosis, cell invasion and migration, cell signaling, DNA damage, glycobiology, cell based assay technology and 3D cell culture techniques - the new resource has been set up to provide researchers with useful background reference information to assist them in their research.

Alex Sim, CEO of AMSBIO commented "For over 20 years we have provided innovative new products and services to researchers throughout the global life science community.  With many of our customers operating at the leading edge of their research specialty - technical papers describing the advances they have achieved, with the assistance of AMSBIO products, will be of interest to many people". He added "This new resource perfectly complements the extensive suite of useful protocols, 'how to' guides and general background information that can be downloaded from our website presentation section (http://www.amsbio.com/presentations.aspx)".

For further information on life science products and services available from AMSBIO please contact the company on +44-1235-828200 / +1-949-768-8365 or email info@amsbio.com.

"Solve your problems - KNAUER Troubleshooting!" - Webinar

In HPLC or UHPLC numerous problems can arise. Especially for inexperienced HPLC-users but also for advanced learners, help in isolating, identifying and correcting typical problems is needed. With this troubleshooting guide, we provide help solving typical and often arising problems. The Webinar will be presented by:
Dr. Silvia Marten
Head of Applications and Columns Department
Wissenschaftliche Gerätebau KNAUER GmbH

Date:	2011-09-23
Time:	10:55 AM - 12:00 PM
Time zone:	(UTC+01) Amsterdam, Berlin, Rom, Wien
Language:	English

To register following this link:   https://webinar.netviewer.com/Pages/WebinarRegistration/WebinarRegistration.jsf

Porvair Filtration Group Report Strong First Half Results

Porvair Filtration Group, specialists in media and equipment for filtration and separation applications, has announced a strong increase in sales for the first half of fiscal year 2011. 

This growth is reflected in the half yearly results reported by parent company - Porvair plc for its microfiltration division where aerospace revenues were up 17% and several large successful bids in the industrial process and nuclear industries contributed to record orders in the second quarter.

Tom Liddell, Managing Director of Porvair Filtration group commented "Our growth has been as a result of an increased sales footprint and operational capability in the US, and from the introduction of a range of new products including fuel tank inerting filters, printing filters and materials for Solid Phase Extraction. As a result, we are looking to expand our workforce, particularly in engineering and purchasing (www.porvairfiltration.com/view/AboutUs/Careers.aspx), by close to 10% this year".

Wyatt Technology’s FFF-MALS Provides Efficient Liposome Characterization

Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular characterization and software, announces that its field flow fractionation (FFF) technology combined with multi-angle light scattering (MALS) and quasi-elastic light scattering (QELS) enables rapid measurements of particle size, size distribution, particle count, as well as structure. The combined system performs the most difficult sizing tasks in key areas of research and development in molecular biology and nanotechnology analyses, including the separation and characterization of liposomes and nanoparticles. This novel technology is illustrated in a new application note, titled “Liposome Characterization by FFF-MALS-QELS”, which is available to download free-of charge via http://www.wyatt.com/files/literature/Field_Flow_Fractionation-Liposome_Characterization.pdf.

Liposomes are made of lipid bilayers. The size of a liposome ranges from some 20 nm up to several micrometers and may be composed of one or several concentric membranes. Liposomes possess unique properties owing to the amphiphilic character of the lipids, which make them suitable for drug delivery. Liposomes have attracted considerable attention as potential vehicles for drug delivery to selected cells or tissues in vivo. Therefore, it is of great importance to monitor liposome size and encapsulation during liposome research, formulation, manufacturing and quality control. However, conventional methods to characterize liposomes fail to perform efficiently and to cover the whole size of liposomes.

In this new application note, a method combining the Wyatt Technology Eclipse FFF system with a DAWN HELEOS and online QELS was used to analyze two liposome samples, one empty, and one filled. The results demonstrated that the combined method is capable of determining the degrees of encapsulation and the internal structures of the two liposomes without making assumptions.

The FFF system offers a number of distinct advantages over column separation techniques for many applications. The method is robust and easy to use, involving minimal shearing and enabling a broad separation range, from small proteins (nm) to large particles (µm). FFF is a non-destructive technique that achieves true particle size distribution and on-line absolute characterization of a wide range of solutions and dispersions. Combined with MALS detectors, the method can determine the absolute size and molar mass distributions as well as the structure and conformation of the particles.

For more information on Wyatt Technology’s instruments or to obtain a copy of the new application note, please visit http://www.wyatt.com/ or email info@wyatt.com.

ProFoss™ for pharmaceutical and chemical applications

ProFoss is now available with the Vision software for pharmaceutical and chemical process applications. ProFoss is a process analysis system based on high resolution diode array technology. It provides non-destructive analysis of pharmaceutical and chemical products directly in the process line without bypass. The solution helps to optimize the use of raw materials and to consistently run production closer to target specifications. Please contact us for more information at: info@foss-nirsystems.com

Custom Manufacture of Applications Optimised Microplates

Specialists in microplate technology - Porvair Sciences Ltd. - have a wealth of technical expertise that have made its custom microplate design and manufacture service second to none. 

Customers are able to benefit from a range of proprietary techniques used in the generation of custom microplates including polymer ultrasonic welding, plasma surface treatment, co-sintering of polymers / silicas and 'two-shot' injection moulding.  Porvair Sciences is also a market leader in the field of moulding ultra-pure plastic materials such as polystyrene, polypropylene and polycarbonate

Steve Knight, Marketing Director of Porvair Sciences, commented "In today's global marketplace increasingly instrument suppliers recognise that 'off-the-shelf' microplates will not always enable them to open up new application markets or gain a competitive edge - consequently our custom microplate design and development business has grown". He added "Customer feedback indicates it is our innovative designs, rapid prototyping, application knowledge and automation-friendly high precision moulding capabilities that were key criteria in Porvair's selection as a development partner'.

Apologies ...

... for the lack of a post yesterday, but I was travelling back from Euroanalysis and couldn't get an Internet connection. Normal service has now been resumed :-)

NEW Flow Cytometer for Gentle Sorting of Large Libraries of 10-1,500µ Particles

Union Biometrica has introduced the NEW COPAS™ HTS Option for Gentle Sorting of large libraries of 10-1,500μ Particles

COPAS large particle flow cytometers can analyze and sort objects that are too large or too fragile for traditional flow cytometers.

Lower operating pressures and soft-touch air-jet diverter technology means even delicate samples like adipocytes or stem cell clusters are dispensed intact and viable.

The new HTS Option package is designed for High Throughput Screening applications involving large numbers of objects to be sorted into large numbers of microtiter output plates.

This option can be added to any new COPAS or BioSorter® model and includes liquid level sensors, leak & clog detectors as well as automatic sample pressure control for walk-away operation. The system stops and activates status lights to notify an operator when reservoirs need refilling or other attention is required. A software option can “slave” the system to a robotic plate handler.

Typical samples include:

·         Bead-based cellular or combi-chem libraries

·         Large cells / clusters (adipocytes, embryoid bodies, pancreatic islets, duct cells, hepatocytes)

·         Small multicellular model organisms (C.elegans, D.melanogaster, Zebrafish)

·         Seeds (Arabidopsis, tobacco)

For additional information email sales@unionbio.com, call 1-(508)-893-3115 (+34 687 859 190 in Europe ) or visit the Union Biometrica website at: http://www.unionbio.com/ .

Strengthening the Oxford Instruments Plasma Technology Executive team

Responding to demand for its leading etch, deposition and growth equipment, Oxford Instruments has invested in many key areas of the business recently and expanded its workforce by over 30% in the past 12 months. The company now announces the appointment of two Directors to the Executive team, Steve Chittock and Neil Perry, who will further contribute to strengthening the company as it moves into its next stage of growth.

Steve Chittock, has been appointed Operations Director (Supply Chain and Manufacturing). A Chartered Engineer, Steve has 20 years operations experience in market leading, multi-national engineering companies operating in aerospace, defence and automotive markets. Steve’s previous employers include Morgan Crucible, SKF & Bostrom. He brings experience in applying advanced manufacturing technology, techniques and software to improve business performance, aligning company and customer needs.

Neil Perry, Finance Director, brings a wealth of experience to Oxford Instruments. This has been gained in a number of industries, including telecommunications, aerospace and automotive. Neil’s previous employers have included Wireless International and Matra Marconi Space (incorporating BAe Space Systems) in commercial, interim and Finance Director roles.

“These two appointments give us considerable strength to meet the needs of our customers and to develop the competencies and resources that support our future growth”, comments Andy Matthews, Managing Director of Oxford Instruments. “In order to remain competitive and produce world leading products, it is imperative that we bring the skills and experience into the Company that meet the needs of the 21^st century, and I believe that these two new appointments will help to achieve this.”

Speed-Up Your Daily Liquid Handling Applications

INTEGRA has produced two new informative videos that demonstrate how its new generation of innovative electronic pipetting tools bridge the gap between traditional handheld pipettes and large robotic systems. The VIAFLO 96 and VIAFLO Voyager deliver to you a higher level of productivity without the cost or training associated with fully automated liquid handling systems.

The VIAFLO 96* is the first handheld electronic pipette which allows simultaneous transfers of 96 samples; there is no easier or faster tool for liquid transfers between 96- and 384-well microplates. The intuitive user interface allows you to dispense to well plates in only seconds without needing to set up complex programs. The VIAFLO 96 is as simple to use as any other pipette in your lab. With the choice of four interchangeable pipetting heads, it allows you to accurately pipette volumes from 0.5 to 1250 microlitres. Typical applications include replication of plates, compressing 96-well plates into a 384-well format, dispensing buffers / master mixes, exchanging culture media and simultaneously starting / stopping 96 reactions.

The VIAFLO Voyager** is the first electronic pipette featuring an automatic mechanism to alter the tip spacing with the press of a button. The VIAFLO Voyager allows you to transfer multiple samples in one go instead of going back and forth with your single channel pipette repeatedly. This not only saves time, but also minimizes the risk of pipetting errors. The tip spacing is freely adjustable and thus helps you to accelerate sample transfers between virtually any lab ware formats including 24-, 48-, 96- and 384- well plates as well as tube racks and SDS / agarose gels. Simply customize the tip spacing to optimally fit your applications needs.

For further information please watch the videos or contact INTEGRA on +41-81-286-9530 / info@integra-biosciences.com (Europe / Asia Pacific) or +1-603-578-5800 / contact@viaflo.com (North / South America).

How Product Resistance Impacts Primary Freeze Drying

SP Scientific, a world leader in freeze drying technology, has released an informative new technical article authored by Dr. Margit Gieseler, GILYOS GmbH and Dr. Henning Gieseler, Freeze Drying Focus Group, University of Erlangen which discusses the impact of product resistance on primary freeze drying.

Freeze drying is known to be a time consuming process with primary drying phases ranging from several hours up to weeks, depending on the product. During primary drying the product temperature at the ice sublimation interface (Tp) must not exceed the critical formulation temperature (collapse or eutectic temperature, respectively) to prevent impairment of final product quality by collapse or meltback. Tp is determined by several factors like chamber pressure, shelf temperature, vial heat transfer coefficient and resistance of the dried layer.

The new technical article** discusses how product resistance (Rp) has been recently suggested as a critical product parameter (CPtP) in freeze drying because it instantaneously draws a picture of the (already dried) inner cake morphology at the point of measurement. From a physical point of view, Rp of the dried product layer impacts the resistance to water vapour flow and thus indirectly determines the maximally allowable shelf temperature and primary drying time.

Further to providing an informative introduction to product resistance behaviour the article summarises the results of trials investigating the product resistance of sucrose based on different experimental conditions and using the Auto-MTM feature of the SP Scientific SMART Freeze Dryer software. The authors conclude resistance of the product to vapour flow during primary drying is a critical product parameter that impacts several process parameters. Lack of information about product performance during primary drying can lead to sub-optimal product quality and/or problems during scale-up. The use of MTM allows an easy and reliable assessment of product resistance data.

To access a copy of 'The relevance of product resistance in freeze drying' please visit the SP Scientific website** or contact the company on telephone +1-845-255-5000 (+44-1473-240000 in Europe).

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New Wireless Data Recorder for J, K, S & T Thermocouples

T&D Corporation has introduced its NEW "Wireless Data Recorder RTR-505TC" which can measure and record temperatures from -199°C to +1,300°C

These new data recorders are compatible with J, K, S & T type thermocouples and accept industry standard miniature connectors.

The RTR-505TC has 15 recording intervals from 1 second to 60 minutes and a capacity to store 16,000 readings.

Additional features include a large LCD display, IP64 water resistance and battery life up to 4 years with "L" version.

The units have a communication range up to 500 ft. which is extendable with a repeater. They are compatible with all TandD RTR-500 Series Wireless Data Collectors which allow for data retrieval to a PC, over a network or the Internet, or through a cellular phone system.

For additional information on these NEW units contact:

TandD CorporationPO Box 321 Saratoga Springs, NY 12866 USA Phone: 518-669-9227 E-mail: inquiries@tandd.com Web: http://www.tandd.com/